Abstract: Systemic lupus erythematosus（SLE） is an autoimmunologic disease that most commonly happens in women of reproductive age. Exposure to estrogen is one of the reasons that may trigger or aggravate lupus. On one hand， SLE itself as well as the treatment may cause ovarian malfunction， premature ovarian failure and osteoporosis. On the other hand， high estrogen status， such as pregnancy or hormonal supplement， may lead to relapse of SLE. As survival rate improves with the development of therapeutic measures，more and more women with SLE come to be faced with the need for pregnancy， assisted reproductive therapy or hormone replacement therapy， which brings up a potential risk of aggravating the disease. This essay aims at reviewing the reproductive healthcare of women with SLE from the aforesaid prospective.

Key words: Lupus erythematosus, systemic, Gonadal steroid hormone, Contraception, Reproductive techniques, assisted