Advances in Fertility Preservation in Women with BRCA Mutations

doi:10.12280/gjfckx.20200287

Abstract

Abstract:

Deleterious mutations in BRCA1 or BRCA2 genes have long been recognized as independent risk factors, mostly for breast and ovarian cancer. Any treatment for the turmor, such as bilateral salpingectomy, inevitably results in damage or loss of fertility. With the general postponement of women′s childbearing age and the younger age of cancer onset, fertility perservation has become a problem that often needs to be faced when making tumor treatment decisions. At the same time, some research evidence suggests that this genetic state may also be associated with ovarian dysfunction, especially the reduction of ovarian reserve. In this paper, we reviewed the fertility problems that BRCA1/2 gene mutation carriers may face and the existing fertility preservation techniques.

Key words: Genes,BRCA1, Genes,BRCA2, Mutation, Fertility, Ovarian reserve, Reproductive techniques,assisted

LIU Xiao-shi, DI Wen. Advances in Fertility Preservation in Women with BRCA Mutations[J]. Journal of International Obstetrics and Gynecology, 2021, 48(1): 71-74.

Figures/Tables 1

References 27

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化疗药物	类别	作用机制	药物作用的细胞周期	不孕风险
5-氟尿嘧啶	抗代谢药物	与四氢叶酸及胸苷酸合成酶（TS）共价结合使其失活,从而阻止DNA复制	S期	低风险
甲氨蝶呤	抗代谢药物	与叶酸竞争性抑制二氢叶酸还原酶,使DNA合成受阻	S期	低风险
博来霉素	蒽环类药物	通过形成毒性氧自由基导致DNA断裂	S期	低风险
紫杉醇	紫杉烷类	有丝分裂过程中通过干扰微管的形成抑制细胞分裂	M期	低风险
更生霉素	抗肿瘤抗生素	与转录起始复合物结合抑制mRNA转录	细胞周期非特异性	中低风险
顺铂	铂类化合物	共价结合DNA双链形成交联,使DNA在复制过程中断裂	细胞周期特异性	中等风险
环磷酰胺	烷基化剂	共价结合DNA双链形成交联,使DNA在复制过程中断裂	细胞周期非特异性	高风险

化疗药物	类别	作用机制	药物作用的细胞周期	不孕风险
5-氟尿嘧啶	抗代谢药物	与四氢叶酸及胸苷酸合成酶（TS）共价结合使其失活,从而阻止DNA复制	S期	低风险
甲氨蝶呤	抗代谢药物	与叶酸竞争性抑制二氢叶酸还原酶,使DNA合成受阻	S期	低风险
博来霉素	蒽环类药物	通过形成毒性氧自由基导致DNA断裂	S期	低风险
紫杉醇	紫杉烷类	有丝分裂过程中通过干扰微管的形成抑制细胞分裂	M期	低风险
更生霉素	抗肿瘤抗生素	与转录起始复合物结合抑制mRNA转录	细胞周期非特异性	中低风险
顺铂	铂类化合物	共价结合DNA双链形成交联,使DNA在复制过程中断裂	细胞周期特异性	中等风险
环磷酰胺	烷基化剂	共价结合DNA双链形成交联,使DNA在复制过程中断裂	细胞周期非特异性	高风险