Abstract: Cervical cancer is the second most common tumor in gynecologic oncology，HPV L1 protein is the major capsid protein of HPV，and it′s expression is closely related to viral replication and early infection. Recent study shows that present screening method simultaneously unites HPV L1 capsid protein　detection may　enhances the accuracy for the screening cervical　disease　and　prediction of progression of lesions． This review is concentrated on update scientific nature and the usability　of the research for detection of HPV L1　capsid protein　in predicting the prognosis and development of cervical disease　a review，looking for the more reasonable screening flow，and choosing the different therapeutic schedule for different patients.

Key words: Papillomaviridae, Viral proteins, Cervical intraepithelial neoplasia, Papillomavirus vaccines, Prognosis