Abstract: Objective：To explore the expression of HIF-1α in cervical cancer and evaluate their relationship. Methods：The published studies were searched in the CNKI （1979 to 2010）， VIP （1989 to 2010），CBMdisc （1979 to 2010） and Wanfang technological periodical full-text databases（1982 to 2010） and other relevant journals were also searched by hand， to identify all the relevant case-control trials，and the quality of the included studies were assessed. The data were analyzed by RevMan 5.0 software. Results：A total of 13 studies involving 862 patients and 243 controls were recruited. Meta-analysis results showed that the positive rate of HIF-1α expression in cervical cancer was significant higher than normal cervical tissues（OR=54.72，95%CI：28.87-103.70），and no significant differences was tested between cervical squamous cell carcinoma vs. non-squamous cell carcinoma（OR=0.82，95%CI：0.39-1.75），and significant differences was tested between lymphnode
metastasis vs. no lymphnode metastasis， poorly differentiatedand vs. well differentiated with OR（95%CI） at 6.24 （2.90-13.44），
5.00（3.18，7.88） respectively. Conclusions：The expression of HIF-1α is significantly associated with cervical cancer and its biological behavior.

Key words: Uterine cervical neoplasms, Carcinoma, Hypoxia-inducible factor 1, alpha subunit, Meta-analysis