Abstract: Ovarian cancer is one of the most sophisticated gynecological problems with undetermined etiology and high mortality， demanding prompt solutions. Although various hypotheses have been introduced previously， none of which can fully elucidate the pathogenesis of ovarian cancer. Recent researches have shown that the immune system is closely associated with neuroendocrine system in patients with ovarian cancer. Estrogen on hypothalamic-pituitary-ovarian axis and Treg、Th17 cells in internal immune environment lay in the same tumor microenvironment of ovarian cancer. Based on this， this review deals with the recent progress and circumstances on interrelations among estrogen、Th17 /Treg and ovarian cancer in order to broaden minds for further study from the perspective of neuro-endocrine-immunoregulatory network.

Key words: Estrogens, T-lymphocytes, Ovarian neoplasms, Carcinoma