Abstract: Interferon-inducible double-stranded RNA （dsRNA）-activated protein kinase R （PKR） is a ubiquitously expressed serine-threonine
kinase which has a special molecular conformation. It is a key cellular target for viral repression and against tumor; it is also a key point of host defense
to trigger cell death in response to virus infection and tumorigenesis. After some oncogenic viruses such as human papillomavirus （HPV）, herpes simplex
virus（HSV）, human cytomegalovirus （HCMV） infect cervix, PKR is usually unactivated which leads to viruses extend and viral oncogenes have an
opportunity to integrate into the host cellular genome to express oncoprotein, disturb the mechanism of cell cycle regulation and apopsis, retard cell to
death, interfere the expression of some key genes to result in long life of some cell clone to induce to malignant change ultimately.

Key words: Human papillomavirus, Herpes simplex virus, Human cytomegalovirus, Protein kinase R, Cervical cancer