Human Papillomavirus Type 16/18 and Cervical Cancer

Journal of International Obstetrics and Gynecology ›› 2010, Vol. 37 ›› Issue (2): 119-121.

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Human Papillomavirus Type 16/18 and Cervical Cancer

SUN Zhi-hui, YUE Tian-fu

Tianjin Medical University General Hospital, Tianjin 300052, China

Received:2009-10-09 Revised:1900-01-01 Published:2010-04-15 Online:2010-04-15

Abstract

Abstract: Human papilloma virus （HPV） 16/18 relates closely with cervical cancer and it plays an important role in the development of cervical
cancer. Cervical squamous cell carcinoma is most easily induced by HPV16 and cervical adenocarcinoma most easily induced by HPV18. Cervical cancer is caused
by HPV 16/18 mainly through carcinogenes is protein E6 E7 of virus genome and anti-oncogene p53 PRb. p53 activity is inhibited by E6 while E7 inactivition of
Rb is inactivated by E7. The common detection method of HPV is in situ hybridization（ISH）, the
molecular hybridization capture Ⅱ（HCⅡ） and polymerase chain reaction （PCR）, etc. Study in preventive and
therapeutic HPV16/18 vaccines is a hot spot. Review on the relationship between HPV16/18 and cervical cancer.

Key words: Human papilloma virus, Cervical cancer, Cancer mechanism, Detection methods, Vaccines

SUN Zhi-hui;YUE Tian-fu. Human Papillomavirus Type 16/18 and Cervical Cancer[J]. Journal of International Obstetrics and Gynecology, 2010, 37(2): 119-121.

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Human Papillomavirus Type 16/18 and Cervical Cancer

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