Abstract:

Cervical cancer is the most common gynecological malignancy in women. With the widespread adoption of tertiary prevention and screening, the incidence of cervical cancer has been gradually decreasing, while the detection rate of cervical intraepithelial neoplasia (CIN) in women of reproductive age has been gradually increasing. Cervical conization is an important method for the diagnosis and treatment of CIN, of which cold knife conization (CKC) and loop electrosurgical excision procedure (LEEP) are commonly used. In recent years, several studies have shown that cervical conization does not significantly affect fertility, but is associated with the occurrence of some adverse pregnancy outcomes, such as preterm delivery, premature rupture of membranes, and cesarean section. The risk of adverse pregnancy outcomes is associated with the conization procedure, the extent of resection, and the postoperative pregnancy interval. The incidence of postoperative adverse pregnancy outcomes increased with the increase in the extent of conization. The efficacy of LEEP and CKC in the treatment of CIN was comparable, but the postoperative pregnancy outcomes of LEEP were better than those of CKC. To reduce the incidence of adverse pregnancy outcomes and decrease the recurrence rate of the lesions, postoperative contraception can be extended, pregnancy monitoring can be strengthened, and if necessary, cervical cerclage and human papilloma virus (HPV) vaccine can be performed.

Key words: Cervical intraepithelial neoplasia, Conization, Pregnancy outcome, Uterine cervical incompetence, Papillomavirus vaccines