Abstract:

High-grade squamous intraepithelial lesion (HSIL) is associated with the persistent infection of high-risk human papilloma virus, are considered cervical precancerous lesions with the potential for cancer. Difficulty of diagnosis and treatment of HSIL are increased due to age-dependent changes to the cervix in postmenopausal women. Though cervical biopsy is the gold standard for diagnosing cervical lesions, it is also missed, but endocervical curettage can improve the accuracy of HSIL in menopausal women, especially when colposcopy is not satisfactory but suspicious cervical lesions. Although positive margins are considered a key factor in residual/recurrence of lesions after cervical resection, a negative margin does not mean that the lesion has been completely removed. Moreover, because of cervical atrophy, cervical shortening, disappearance of the vaginal vault and other reasons, the difficulty of cervical resection surgery and the risk of damage to adjacent organs such as bladder and rectum are increased. At the same time, the hormone level of menopausal women is reduced, the predilection site of cervical cancer transformation zone of cervical moved to the cervical canal, and colposcopy cannot find the suspicious part in time, resulting in missed diagnosis of cervical cancer. Therefore, it is of great clinical significance to explore the optimal scheme for diagnosis and treatment of cervical lesions in postmenopausal women. By analyzing the current status and problems faced by cervical HSIL in postmenopausal, it provides individualized theoretical guidance for the diagnosis and treatment of cervical lesions in them.

Key words: Squamous intraepithelial lesions of the cervix, Postmenopause, Cervix uteri, Cervical intraepithelial neoplasia, High-risk human papilloma virus