Research Progress of Uterine Collision Tumor

doi:10.12280/gjfckx.20210240

Abstract

Abstract:

Uterine collision tumor is a rare pathological type composed of two or more malignant tumors with few related reports. Its etiology and pathogenesis are still unclear. Clinical manifestations and imaging examinations are not specific, and preoperative diagnosis is difficult, mainly rely on pathological examination to make an accurate diagnosis. There are various histological types of uterine collision tumors, while no standardized treatment guidelines have been established so far. The comprehensive treatment mainly consists of surgery and radiotherapy, supplemented by chemotherapy, and the prognosis is quite different. In recent years, the incidence of uterine malignant tumors has been increasing. With the extensive use of experimental techniques such as immunohistochemistry, Western blotting, and polymerase chain reaction (PCR) in clinical pathology, the detection rate of uterine collision tumors has been increased. This article reviews the clinical features, diagnosis and treatment of uterine collision tumors, in order to increase people′s comprehensive understanding of uterine collision tumors, making early and accurate diagnosis, and implement clinical intervention measures to improve the prognosis of patients.

Key words: Uterine neoplasms, Cervix uteri, Diagnosis, Therapy, Collision tumors

AN Jing, KANG He-yao, XING Yi-juan, LI Hong-li, YANG Yong-xiu. Research Progress of Uterine Collision Tumor[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 15-18.

References 33

[1]	Shu P, Li R, Xie D, et al. Clinical profile and treatment outcome of collision carcinoma in cervix[J]. Medicine(Baltimore), 2020, 99(11):e19131. doi: 10.1097/MD.0000000000019131. doi: 10.1097/MD.0000000000019131
[2]	王宏量, 孙亚昕, 李加美, 等. 食管碰撞瘤的研究进展[J]. 国际肿瘤学杂志, 2017, 44(3):221-223. doi: 10.3760/cma.j.issn.1673-422X.2017.03.016. doi: 10.3760/cma.j.issn.1673-422X.2017.03.016
[3]	Schizas D, Katsaros I, Michalinos A, et al. Collision Tumors of the Gastrointestinal Tract: A Systematic Review of the Literature[J]. Anticancer Res, 2018, 38(11):6047-6057. doi: 10.21873/anticanres.12955. doi: 10.21873/anticanres.12955
[4]	Mishra A, Shamsunder S, Malik S, et al. Collision tumour of ovary: a rare combination of fibrothecoma with serous cystadenoma[J]. Int J Reprod Contracept Obstet Gynecol, 2017, 6(4):1643-1645.doi: 10.18203/2320-1770.ijrcog20171444. doi: 10.18203/2320-1770.ijrcog20171444
[5]	Gebauer N, Merz H, Ottmann KW, et al. Lymphoepithelioma-like carcinoma and simultaneous marginal zone lymphoma of the skin: a case report[J]. Am J Dermatopathol, 2014, 36(2):e26-e29. doi: 10.1097/DAD.0b013e318297caef. doi: 10.1097/DAD.0b013e318297caef
[6]	Yang GZ, Liang SH, Shi XH. A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast[J]. Diagn Pathol, 2020, 15(1):76. doi: 10.1186/s13000-020-00992-2. doi: 10.1186/s13000-020-00992-2
[7]	Kim G, Pham HQ, Ramzan A, et al. Endometrioid adenocarcinoma associated with endometrial stromal sarcoma: A rare, often unrecognized collision tumor[J]. Gynecol Oncol Rep, 2015, 13:8-12. doi: 10.1016/j.gore.2015.04.005. doi: 10.1016/j.gore.2015.04.005
[8]	Rivera G, Niu S, Chen H, et al. Collision Tumor of Endometrial Large Cell Neuroendocrine Carcinoma and Low-Grade Endometrial Stromal Sarcoma: A Case Report and Review of the Literature[J]. Int J Surg Pathol, 2020, 28(5):569-573. doi: 10.1177/1066896920901764. doi: 10.1177/1066896920901764
[9]	Kim JH. Torsion of Collision Tumor: Dermoid Cyst and Fibrothecoma with Postmenopausal Bleeding[J]. J Menopausal Med, 2016, 22(2):114-117. doi: 10.6118/jmm.2016.22.2.114. doi: 10.6118/jmm.2016.22.2.114
[10]	Merrill SA, Sharma A, Carlin RE, et al. A Rare Intracranial Collision Tumor of Meningioma and Metastatic Uterine Adenocarcinoma: Case Report and Literature Review[J]. World Neurosurg, 2021, 145:340-347. doi: 10.1016/j.wneu.2020.09.108. doi: 10.1016/j.wneu.2020.09.108 pmid: 32987172
[11]	McCroskey Z, Sim SJ, Selzman AA, et al. Primary collision tumors of the kidney composed of oncocytoma and papillary renal cell carcinoma: A review[J]. Ann Diagn Pathol, 2017, 29:32-36. doi: 10.1016/j.anndiagpath.2017.04.011. doi: S1092-9134(17)30130-2 pmid: 28807339
[12]	Lovell MO, Valente PT. Unique collision of hodgkin lymphoma and adenosquamous carcinoma in the uterine cervix: synchronous malignant neoplasms of the cervix[J]. J Low Genit Tract Dis, 2003, 7(4):307-310. doi: 10.1097/00128360-200310000-00015. doi: 10.1097/00128360-200310000-00015
[13]	李慧, 李雷, 唐霄, 等. 子宫颈碰撞癌13例临床病理分析[J]. 中华病理学杂志, 2014(9):627-628. doi: 10.3760/cma.j.issn.0529-5807.2014.09.013. doi: 10.3760/cma.j.issn.0529-5807.2014.09.013
[14]	Tanveer N, Gupta B, Pathre A, et al. A Rare Collision Tumour of Uterus-Squamous Cell Carcinoma and Endometrial Stromal Sarcoma[J]. J Clin Diagn Res, 2017, 11(2):ED20-ED22. doi: 10.7860/JCDR/2017/23532.9405. doi: 10.7860/JCDR/2017/23532.9405
[15]	Jang KS, Lee WM, Kim YJ, et al. Collision of three histologically distinct endometrial cancers of the uterus[J]. J Korean Med Sci, 2012, 27(1):89-92. doi: 10.3346/jkms.2012.27.1.89. doi: 10.3346/jkms.2012.27.1.89 pmid: 22219620
[16]	Masuyama H, Haraga J, Nishida T, et al. Three histologically distinct cancers of the uterine corpus: A case report and review of the literature[J]. Mol Clin Oncol, 2016, 4(4):563-566. doi: 10.3892/mco.2016.770. doi: 10.3892/mco.2016.770 pmid: 27073663
[17]	Shi X, Wu S, Huo Z, et al. Co-existing of adenoid cystic carcinoma and invasive squamous cell carcinoma of the uterine cervix: a report of 3 cases with immunohistochemical study and evaluation of human papillomavirus status[J]. Diagn Pathol, 2015, 10:145. doi: 10.1186/s13000-015-0376-z. doi: 10.1186/s13000-015-0376-z
[18]	Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J]. CA Cancer J Clin, 2021, 71(3):209-249. doi: 10.3322/caac.21660. doi: 10.3322/caac.21660
[19]	Hancock G, Hellner K, Dorrell L. Therapeutic HPV vaccines[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 47:59-72. doi: 10.1016/j.bpobgyn.2017.09.008. doi: S1521-6934(17)30141-4 pmid: 29108943
[20]	舒思楠, 许梦梵, 叶红, 等. 子宫碰撞瘤1例[J]. 巴楚医学, 2020, 3(2):98-100. doi: 10.3969/j.issn.2096-6113.2020.02.023. doi: 10.3969/j.issn.2096-6113.2020.02.023
[21]	Liang H, Griffith CC, Ma L, et al. The sensitivity of Pap cytology and HPV testing to detect incident cervical cancer: prior testing results in 178 patients with invasive cervical cancer at a large general hospital in China[J]. J Am Soc Cytopathol, 2016, 5(2):64-70. doi: 10.1016/j.jasc.2015.06.001. doi: 10.1016/j.jasc.2015.06.001
[22]	杨盼, 张梦真. 人乳头瘤病毒检测阴性子宫颈癌的研究进展[J]. 现代肿瘤医学, 2021, 29(2):345-348. doi: 10.3969/j.issn.1672-4992.2021.02.036. doi: 10.3969/j.issn.1672-4992.2021.02.036
[23]	Cavalcanti MS, Schultheis AM, Ho C, et al. Mixed Mesonephric Adenocarcinoma and High-grade Neuroendocrine Carcinoma of the Uterine Cervix: Case Description of a Previously Unreported Entity With Insights Into Its Molecular Pathogenesis[J]. Int J Gynecol Pathol, 2017, 36(1):76-89. doi: 10.1097/PGP.0000000000000306. doi: 10.1097/PGP.0000000000000306 pmid: 27532149
[24]	Pirog EC. Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors[J]. Arch Pathol Lab Med, 2017, 141(12):1653-1667. doi: 10.5858/arpa.2016-0356-RA. doi: 10.5858/arpa.2016-0356-RA
[25]	Nicolás I, Marimon L, Barnadas E, et al. HPV-negative tumors of the uterine cervix[J]. Mod Pathol, 2019, 32(8):1189-1196. doi: 10.1038/s41379-019-0249-1. doi: 10.1038/s41379-019-0249-1
[26]	Chandanwale SS, Pal SS, Kumar HB, et al. Serous Cystadenoma and Fibrothecoma: A Rare Combination in Collision Tumor of Ovary with Pseudo-Meigs Syndrome[J]. J Pathol Transl Med, 2015, 49(2):163-166. doi: 10.4132/jptm.2013.11.25. doi: 10.4132/jptm.2013.11.25 pmid: 26148741
[27]	Snyder R, Fayed I, Dowlati E, et al. Pituitary Adenoma and Craniopharyngioma Collision Tumor: Diagnostic, Treatment Considerations, and Review of the Literature[J]. World Neurosurg, 2019, 121:211-216. doi: 10.1016/j.wneu.2018.10.048. doi: S1878-8750(18)32345-3 pmid: 30326307
[28]	Kersemaekers AM, van de Vijver MJ, Fleuren GJ. Comparison of the genetic alterations in two epithelial collision tumors of the uterine cervix. A report of two cases[J]. Int J Gynecol Pathol, 2000, 19(3):225-230. doi: 10.1097/00004347-200007000-00005. doi: 10.1097/00004347-200007000-00005 pmid: 10907170
[29]	莫祥兰, 韦荣干, 黄谟婉, 等. 宫颈碰撞癌1例并文献复习[J]. 山东医药, 2013, 53(20):80-82. doi: 10.3969/j.issn.1002-266X.2013.20.029. doi: 10.3969/j.issn.1002-266X.2013.20.029
[30]	Lewis JS Jr, Chernock RD, Bishop JA. Squamous and Neuroendocrine Specific Immunohistochemical Markers in Head and Neck Squamous Cell Carcinoma: A Tissue Microarray Study[J]. Head Neck Pathol, 2018, 12(1):62-70. doi: 10.1007/s12105-017-0825-y. doi: 10.1007/s12105-017-0825-y pmid: 28528398
[31]	周晖, 刘昀昀, 罗铭, 等. 《2021 NCCN子宫颈癌临床实践指南(第1版)》解读[J]. 中国实用妇科与产科杂志, 2020, 36(11):1098-1104. doi: 10.19538/j.fk2020110115. doi: 10.19538/j.fk2020110115
[32]	Kaushal S, Mathur SR, Kumar S. Coexisting squamous cell carcinoma and high-grade neuroendocrine carcinoma, small cell type: a rare collision in cervix[J]. BMJ Case Rep, 2018, 2018: bcr-2017-223127. doi: 10.1136/bcr-2017-223127. doi: 10.1136/bcr-2017-223127
[33]	Fukunaga H, Asama H, Kaneda H, et al. Collision tumor with diffuse large B cell lymphoma and gastric cancer[J]. Jpn J Clin Oncol, 2016, 46(10):968-969. doi: 10.1093/jjco/hyw084. doi: 10.1093/jjco/hyw084