胎盘蛋白13对子痫前期早期预测及治疗的价值

doi:10.12280/gjfckx.20200776

摘要/Abstract

摘要：

子痫前期是指妊娠20周后,以高血压和蛋白尿为主要临床表现的妊娠相关疾病,目前仍是威胁全球母婴结局的主要原因。若该疾病不加以控制可导致母体HELLP综合征、子痫、胎盘早剥等并发症,部分可致胎儿生长受限,甚至引起胎死宫内等严重不良妊娠结局,但当前尚无有效的生物标志物对子痫前期进行早期预测。多数学者认为,子痫前期是以胎盘受损为主要原因的多因素综合作用的结果,考虑胎盘蛋白13（placental protein 13,PP13）作为胎盘特异性蛋白之一,在胎盘滋养细胞中高度表达,故结合国内外最新文献,通过对PP13及其在母体妊娠生理和子痫前期发生发展过程中的作用,探讨PP13作为子痫前期早期预测的潜在标志物及其在靶向治疗方面的应用前景。

关键词: 妊娠蛋白质类, 先兆子痫, 妊娠结局, 预测, 胎盘蛋白13

Abstract:

Pre-eclampsia, a pregnancy-related condition characterized by hypertension and proteinuria after 20 weeks of gestation, remains a major threat to maternal and infant outcomes globally. If this disease is not controlled, it may lead to maternal HELLP syndrome, eclampsia, placental abruption and other complications, some of which may lead to fetal intrauterine growth restriction, and even cause fetal death and serious adverse pregnancy outcomes in utero. However, currently there is no effective biomarker for early prediction of pre-eclampsia. Most scholars believe that pre-eclampsia is the result of a multi-factorial effect mainly due to damage to the placenta, considering the placenta protein 13 (PP13) as one of the placenta protein specificity, high expression in placenta nourish cells, therefore, this review combines the latest literatures at home and abroad, introduces the PP13 in maternal pregnancy physiological factors and its effect in the development process of pre-eclampsia, discusses the PP13 as pre-eclampsia early prediction of potential markers and its application prospect in terms of targeted therapy.

Key words: Pregnancy proteins, Pre-eclampsia, Pregnancy outcome, Forecasting, Placenta protein 13

杨育妮, 杨超, 王渠源. 胎盘蛋白13对子痫前期早期预测及治疗的价值[J]. 国际妇产科学杂志, 2021, 48(2): 178-181.

YANG Yu-ni, YANG Chao, WANG Qu-yuan. The Value of Placenta Protein 13 in Early Prediction and Treatment of Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2021, 48(2): 178-181.

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