RUNX3在妇科肿瘤中的研究进展

doi:10.12280/gjfckx.20201031

摘要/Abstract

摘要：

宫颈癌、子宫内膜癌和卵巢癌是妇科最常见的三大恶性肿瘤,严重威胁女性的生命安全。DNA甲基化是重要的表观遗传学机制之一,可导致抑癌基因的沉默,最终促成肿瘤的发生。RUNX3是目前抑癌基因研究的热门之一,在细胞生长、增殖、分化、凋亡和信号转导中有着重要作用。RUNX3启动子甲基化会导致其表达沉默,在妇科肿瘤的发生发展中有着举足轻重的作用。甲基化抑制剂可以诱导RUNX3的重新表达,达到治疗肿瘤的目的。肿瘤的发生、生长及转移与肿瘤细胞所处的内外环境有着紧密关联,会形成独特的肿瘤微环境,RUNX3可通过多种作用对其进行调控。随着RUNX3在妇科肿瘤中作用机制的研究不断深入,必将为其成为妇科肿瘤诊断标志物及其靶向治疗打下基础。综述RUNX3在妇科肿瘤中的研究进展,以期为临床工作提供新思路。

Abstract:

Cervical cancer, endometrial cancer and ovarian cancer are the three most common malignant tumors in gynecology, which seriously threaten the life and safety of women. DNA methylation is one of the important epigenetic mechanisms, which can lead to the silencing of tumor suppressor genes and ultimately lead to tumorigenesis. RUNX3 is one of the hot topics in the research of tumor suppressor genes, which plays an important role in cell growth, proliferation, differentiation, apoptosis and signal transduction. RUNX3 promoter methylation will lead to its expression silence, which plays an important role in the occurrence and development of gynecological tumors. Methylation inhibitors can induce the re-expression of RUNX3 to achieve the purpose of tumor treatment. The occurrence, growth and metastasis of tumor are closely related to the internal and external environment of tumor cells, which will form a unique tumor microenvironment. RUNX3 can regulate it through a variety of actions. With the further study of the mechanism of RUNX3 in gynecological tumors, it will lay a foundation for it to become a diagnostic marker and targeted therapy of gynecological tumors. To summarize the research progress of RUNX3 in gynecological tumors, in order to provide new ideas for clinical work.

Key words: RUNX3, Genital neoplasms,female, DNA methylation, DNA-binding proteins, Tumor microenvironment

何洪月, 谭文华. RUNX3在妇科肿瘤中的研究进展[J]. 国际妇产科学杂志, 2021, 48(4): 438-442.

HE Hong-yue, TAN Wen-hua. Research Progress of RUNX3 in Gynecological Oncology[J]. Journal of International Obstetrics and Gynecology, 2021, 48(4): 438-442.

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