妊娠期母体肠道菌群与子代疾病相关性的研究进展

doi:10.12280/gjfckx.20210469

摘要/Abstract

摘要：

随着基因测序技术的发展,肠道菌群与疾病的发生发展成为当前生物医学领域的研究热点。对孕妇这一特殊群体的肠道微生态的研究更是备受关注。妊娠期为满足胎儿生长发育的需要,母体除生殖、循环、消化和内分泌等系统发生一系列生理性适应性变化外,肠道菌群的结构和数量也会发生相应的变化。妊娠期母体高脂/低纤维的饮食结构、孕妇肥胖、妊娠期使用抗生素等因素会导致母体的肠道微生物群失衡,从而可能会增加子代发生肥胖症、免疫系统疾病和神经系统疾病的风险。因此适时对妊娠期母体进行肠道微生物群的检测,以便及时干预调节失调的肠道菌群,同时对孕妇进行健康宣教,可降低子代各种疾病的发生风险,提高人口整体身体素质。

关键词: 胃肠道微生物组, 孕妇, 肥胖症, 免疫系统疾病, 神经系统疾病

Abstract:

With the development of gene sequencing technology, the relationship between the intestinal flora and the occurrence and development of diseases has become a research hotspot in biomedical field. The research on intestinal microecology of pregnant women has attracted much attention. In order to meet the needs of fetal growth and development during pregnancy, in addition to a series of physiological adaptations in reproduction, circulation, digestion, and endocrine, the structure and quantity of the intestinal flora will also change. Factors such as maternal high-fat/low-fiber diet during pregnancy, maternal obesity, and antibiotic use during pregnancy can lead to an imbalance of the maternal intestinal microbiota, which may increase the risk of obesity, immune system diseases, nervous system diseases in the offspring. Therefore, detection of the intestinal micro-organisms in pregnant women at the right time can timely intervene and regulate the dysfunctional intestinal flora. At the same time, enhancing health education for pregnant women can reduce the risk of various diseases among the offspring and improve the overall physical quality of the population.

Key words: Gastrointestinal microbiome, Pregnant women, Obesity, Immune system diseases, Nervous system diseases

王瑜, 詹佳梅, 罗晓红. 妊娠期母体肠道菌群与子代疾病相关性的研究进展[J]. 国际妇产科学杂志, 2022, 49(1): 67-70.

WANG Yu, ZHAN Jia-mei, LUO Xiao-hong. Research Progress on the Relationship between Maternal Intestinal Flora during Pregnancy and Offspring Diseases[J]. Journal of International Obstetrics and Gynecology, 2022, 49(1): 67-70.

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