子痫前期PI3K/Akt通路相关非编码RNA的研究进展

doi:10.12280/gjfckx.20220530

摘要/Abstract

摘要：

子痫前期（pre-eclampsia）是妊娠期常见并发症之一，是导致孕产妇和围生儿死亡的重要原因。子痫前期的发生与胎盘滋养细胞功能障碍密切相关。胎盘滋养细胞侵袭不全和子宫螺旋动脉重铸异常是子痫前期发生的主要病理机制。磷脂酰肌醇3激酶/蛋白激酶B（phosphatidylinositol-3 kinase/protein kinase B，PI3K/Akt）通路对胎盘滋养细胞的增殖、存活、凋亡、迁移和侵袭等过程具有重要调节作用。非编码RNA（non-coding RNA，ncRNA）中的微小RNA、长链非编码RNA和环状RNA具有重要的多水平基因调控功能，在PI3K/Akt通路中发挥重要调节作用，影响胎盘滋养细胞的功能，与子痫前期的发生、发展相关。综述近年子痫前期PI3K/Akt通路相关ncRNA的研究进展，为探索和发现子痫前期发病机制中的关键分子提供参考。

关键词: 先兆子痫, 磷脂酰肌醇3激酶/蛋白激酶B通路, 非编码RNA, 信号传导

Abstract:

Pre-eclampsia is one of the common complications of pregnancy and is an important cause of maternal and perinatal mortality. The disordered functions of placental trophoblast cells are closely associated with the development of pre-eclampsia. Inadequate invasion of placental extravillous trophoblast cells and abnormal spiral artery remodelling are dominant pathologic mechanisms in pre-eclampsia. The PI3K/Akt (phosphatdylinositol-3 kinase/protein kinase B) signalling pathway plays a significant role in regulating proliferation, survival, apoptosis, migration, and invasion of trophoblast cells. MicroRNAs (miRNAs), long non-coding RNAs and circular RNAs belonging to non-coding RNAs (ncRNA) have multi-level regulatory roles on genes and influence the functions of trophoblast cells by regulating the PI3K/Akt signalling pathway, thus contributing to the occurrence and development of pre-eclampsia. This review introduces the recent advances of ncRNAs related to PI3K/Akt signalling pathway in pre-eclampsia in an effort to provide a reference for exploring and discovering key molecules in the pathogenesis of pre-eclampsia.

Key words: Pre-eclampsia, Phosphatidylinositol 3-kinase/protein kinase B signalling pathway, non-coding RNA, Signal transduction

徐丹晨, 程蔚蔚. 子痫前期PI3K/Akt通路相关非编码RNA的研究进展[J]. 国际妇产科学杂志, 2023, 50(1): 54-58.

XU Dan-chen, CHENG Wei-wei. Research Progress of Non-Coding RNAs Relating to PI3K/Akt Pathway in Pre-Eclampsia[J]. Journal of International Obstetrics and Gynecology, 2023, 50(1): 54-58.

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