免疫检查点抑制剂在妇科恶性实体肿瘤中的研究进展

doi:10.12280/gjfckx.20220578

摘要/Abstract

摘要：

妇科恶性实体肿瘤严重威胁女性生命健康，晚期、复发性及转移性妇科肿瘤的放化疗等辅助治疗效果欠佳，预后较差。近年来，以免疫检查点抑制剂为主的免疫疗法在恶性实体肿瘤的治疗中显示出较好的疗效，也为妇科恶性实体肿瘤患者提供了新的治疗选择。但在传统含铂化疗失败行免疫检查点抑制剂单药治疗的效果仍然较差，可能与多周期化疗后患者受损的免疫系统难以发生有效的免疫应答有关。众多临床研究显示，将免疫检查点抑制剂应用前置和免疫检查点抑制剂联合含铂化疗方案可使晚期、复发性和转移性妇科恶性实体肿瘤的患者获益。综述免疫检查点抑制剂在妇科恶性实体肿瘤中的应用进展。

关键词: 免疫检查点抑制剂, 免疫疗法, 宫颈肿瘤, 子宫内膜肿瘤, 卵巢肿瘤, 综合疗法

Abstract:

Gynecological solid cancers severely threaten women′s health. Adjuvant treatment such as radiotherapy and chemotherapy for advanced, recurrent and metastatic gynecological tumors is ineffective and the prognosis is poor. In recent years, immunotherapy based on immune checkpoint inhibitors has shown good efficacy in the treatment of malignant solid tumors, and also provides new treatment options for patients with gynecological malignant solid tumors. However, the effect of immune checkpoint inhibitors monotherapy in the failure of traditional platinum-based chemotherapy is poor, which may be related to the difficulty of effective immune response in patients with impaired immune system after multi-cycle chemotherapy. Many clinical studies have shown that immune checkpoint inhibitors combined with platinum-based chemotherapy and pre-application of immune checkpoint inhibitors can benefit patients with advanced, recurrent and metastatic gynecological malignant solid tumors. This article reviews the application progress of immune checkpoint inhibitors in gynecological malignant solid tumors.

Key words: Immune checkpoint inhibitors, Immunotherapy, Uterine cervical neoplasms, Endometrial neoplasms, Ovarian neoplasms, Combined modality therapy

刘德高, 张舒荣, 高悦文, 邹永辉, 李长忠. 免疫检查点抑制剂在妇科恶性实体肿瘤中的研究进展[J]. 国际妇产科学杂志, 2022, 49(6): 601-605.

LIU De-gao, ZHANG Shu-rong, GAO Yue-wen, ZOU Yong-hui, LI Chang-zhong. Advances in Immune Checkpoint Inhibitors for Gynecological Malignant Solid Tumors[J]. Journal of International Obstetrics and Gynecology, 2022, 49(6): 601-605.

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