光动力疗法在女性生殖道疾病中的应用进展

doi:10.12280/gjfckx.20220798

摘要/Abstract

摘要：

光动力疗法（photodynamic therapy，PDT）是一种新型的、非侵入性的治疗方式，其是基于局部或全身应用光敏剂，光敏剂在病变部位特异性聚集，当以适当波长的光照射病变部位，光敏剂吸收光能启动活化过程后发挥选择性破坏病变细胞的作用。PDT主要治疗皮肤、黏膜病变或肿瘤，具有创伤小、选择性好、可重复治疗、保护器官结构及功能等特点。随着女性生殖道疾病发病趋于年轻化，患者对保留原有器官结构、生育功能等治疗要求日益增加，为避免传统治疗手段导致的瘢痕、溃烂、器官结构或功能损伤等不良反应，近年来PDT在女性尖锐湿疣、宫颈阴道鳞状上皮内病变和外阴病变等疾病中的应用逐渐展开并已发挥优势。

关键词: 光化学疗法, 女（雌）性泌尿生殖系统疾病, 生殖道感染, 宫颈上皮内瘤样病变, 乳头状瘤病毒感染

Abstract:

Photodynamic therapy (PDT) is a novel, non-invasive treatment modality based on topical or systemic application of photosensitizer, which concentrates photosensitizer specifically at the lesion site. When the lesion site is irradiated with the appropriate wavelength of light, photosensitizer is initiate the activation process by the absorption of light energy, thus plays a role in the selective destruction of diseased cells. PDT is mainly used to treat skin and mucosal lesions or tumors. It has the characteristics of small trauma, good selectivity, repeatable treatment, and protection of organ structure and function. As the incidence of female genital tract diseases tends to be younger, people′s requirements for preserving the original organ structure and reproductive function protection after treatment are increasing. In order to avoid the side effects of scar, ulceration, organ structure or function injury caused by traditional treatment methods, in recent years, the application of PDT in female condyloma acuminatum, cervical/vaginal squamous intraepithelial lesions, and vulvar lesions has gradually expanded and played its advantages.

Key words: Photochemotherapy, Female urogenital diseases, Reproductive tract infections, Cervical intraepithelial neoplasia, Papillomavirus infections

梅士豪, 王悦. 光动力疗法在女性生殖道疾病中的应用进展[J]. 国际妇产科学杂志, 2023, 50(2): 185-189.

MEI Shi-hao, WANG Yue. Application of Photodynamic Therapy in Female Reproductive Tract Diseases[J]. Journal of International Obstetrics and Gynecology, 2023, 50(2): 185-189.

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