国际妇产科学杂志

国际妇产科学杂志 ›› 2009, Vol. 36 ›› Issue (5): 371-372.

• 综述 • 上一篇    下一篇

RNA干扰技术治疗妇科恶性肿瘤

冯坤;周怀君   

  1. 210029 南京中医药大学中西医结合鼓楼医学院(冯 坤)；南京市鼓楼医院(周怀君)
  • 收稿日期:2008-11-28 修回日期:1900-01-01 出版日期:2009-10-15 发布日期:2009-10-15

The Research of RNA Interference in the Treatment of Gynecological Malignant Tumor

FENG Kun;ZHOU Huai-jun   

  1. Gulou Clinical Medical College of Integrative Chinese-western Medicine, The No.1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing 210029, China （FENG Kun）; The Drum Tower Hospital, Nanjing 210008, China （ZHOU Huai-jun）
  • Received:2008-11-28 Revised:1900-01-01 Published:2009-10-15 Online:2009-10-15

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摘要： RNA干扰（RNAi）是双链RNA诱导细胞内特定基因沉默的现象。随着对RNAi技术研究的不断深入，其作用机制正在被逐步阐明，RNAi技术也日趋完善和成熟，已广泛应用于许多研究领域，如功能基因学，微生物学，基因表达调控机制研究等领域。在肿瘤方面，更取得突破性进展，为肿瘤的基因治疗开辟了新的有效途径。就RNAi技术在妇科恶性肿瘤方面的应用进展综述。

关键词: RNA干扰, 宫颈癌, 卵巢癌, 子宫内膜癌

Abstract: RNA interference （RNAi） is a post-transportational gene silencing induced by introduction of
double-stranded RNA. With the deepening study of RNAi technology, its mechanism is being clarified gradually. RNAi technology is also becoming more perfect and mature, and has been widely used in many research areas, such as functional genome, microbiology and regulatory mechanism of gene expression. And a breakthrough has been made in the field of tumor therapy. So it has opened a new effective way in tumor area. This article will provide a review on the application of RNAi technology on gynecologic malignant.

Key words: RNA interference, Cervical cancer, Ovarian cancer, Endometrial cancer