国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (2): 90-92.
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高晓丽,牛秀敏
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GAO Xiao-li, NIU Xiu-min
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摘要： 蛋白酪氨酸磷酸酶1B与胰岛素抵抗密切相关，主要通过胰岛素信号转导通路导致信号转导障碍。胰岛素抵抗（IR）是妊娠期糖尿病（GDM）发病的主要原因，胰岛素受体信号传导障碍可能是GDM发生的重要机制。探讨蛋白酪氨酸磷酸酶1B与GDM胰岛素信号转导的关系，进一步研究GDM胰岛素抵抗发生的机制，以早期预防和干预GDM，减少母儿并发症。
关键词: 蛋白酪氨酸磷酸酶1B, 妊娠期糖尿病, 胰岛素抵抗, 胰岛素信号转导
Abstract: Protein tyrosine phosphatase 1B （PTP 1B） has close relationship with insulin resisitance by inhibiting the insulin signal transduction pathway. Insulin resistance is the main cause of pathogenetic in Gestational diabetes mellitus, and the insulin signal transduction pathway may be the important cellular mechanisms of GDM. Investigating the relationship between PTP 1B and GDM insulin signal transduction, further, to research mechanisms of insulin resistance in GDM, for preventing and interfering GDM, reducing the complications of maternity and fetus
Key words: Protein tyrosine phosphatase 1B, Gestational diabetes mellitus, Insulin resistance, Insulin signal transduction
高晓丽;牛秀敏. 蛋白酪氨酸磷酸酶1B与GDM胰岛素信号转导[J]. 国际妇产科学杂志, 2010, 37(2): 90-92.
GAO Xiao-li;NIU Xiu-min. Protein Tyrosine Phosphatase 1B and Insulin Signal Transduction in Gestational Diabetes Mellitus[J]. Journal of International Obstetrics and Gynecology, 2010, 37(2): 90-92.
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https://www.gjfckx.ac.cn/CN/Y2010/V37/I2/90
