国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (3): 204-207.

• 综述 • 上一篇    下一篇

G蛋白耦联受体30与激素依赖性肿瘤

郭会敏,郭瑞霞   

  1. 450052 郑州大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-06-15 发布日期:2010-06-15

The Research of G Protein Coupled Receptor 30 and Hormone-dependent Tumor

GUO Hui-min, GUO Rui-xia   

  1. Department of Obstetrics and Gynecology， the First Affiliated Hospital of ZhengZhou University，ZhengZhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-06-15 Online:2010-06-15

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摘要： 雌激素是类固醇激素家族中的一员，是人体中一种重要的激素，调节多种组织与器官的生理与病理效应。传统认为雌激素像其他类固醇激素一样是一个核转录因子，通过“核转录效应”发挥作用，然而该作用机制并没有使激素依赖性肿瘤得到有效的控制。近年来研究表明雌激素还具有生长因子样的“非核效应”，该过程仅需要数秒钟至数十分钟，因此又称“快速效应”。研究表明，G蛋白耦联受体30（GPR30）介导了雌激素的“非核效应”。GPR30与雌激素结合后可快速活化细胞内第二信使信号，诱导细胞外信号调节激酶（ERK）活化、磷脂酰肌醇3激酶（PI3K）活化、钙动员及环磷酸腺苷（cAMP）生成等，参与雌激素非核效应的调节及雌激素依赖性肿瘤的发生和发展。

关键词: G蛋白耦联受体, 雌激素受体, 雌激素, 信号转导

Abstract: Estrogen is one member of the family of steroid hormones, it is a critical hormone in the human body, induces diverse physiological and pathohysiological effects. The traditional view that estrogen like other steroids, is a nuclear transcription factor, mediate it’s primary effects at the genomic level. However, hormone- dependent tumors are not so effective control by the mechanism of estrogen. In recent years, a large number of reports show that in addition to transcriptional regulation, estrogen also mediates cellular effects with response times from seconds to minutes. A large number of researches have shown that G Protein-Coupled Receptor30 part in the nongenomiceffects of estrogen. When GPR30 combined with estrogen，it can rapid activated the intracellular second signaling system , including ERK activation, PI3K activation, calcium mobilization, cAMP production and so on, which play an important role in the nongenomiceffect of estrogen. In this review，we will focus on the relations between GPR30 and estrogen-related tumors.

Key words: GPR30, Estrogen receptor, Estrogen, Signaling