国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 325-328.

• 综述 • 上一篇    下一篇

上皮性卵巢癌病因学研究进展

张旭垠, 华克勤

  

  1. <SPAN lang=EN-US style=
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15

Progress in Study on Etiology of Ovarian Epithelial Cancer

ZHANG Xu-yin, HUA Ke-qin   

  1. Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15

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摘要： 上皮性卵巢癌因难以早期发现而导致病死率高。有效的早期筛查或治疗都应基于对疾病发病机制的详细了解。传统观点认为，卵巢癌的所有亚型都来源于卵巢表面上皮（OSE），但其具有一定的局限性。基于对BRCA基因突变且罹患隐匿输卵管癌患者的一系列研究发现，上皮性卵巢癌可能起源于输卵管伞部。研究OSE和皮质包涵囊肿（CICs）模式、两条通路模式和卵巢癌起源于输卵管模式这3种上皮性卵巢癌可能的发生发展途径，以期为早期诊疗研究提供帮助。

关键词: 卵巢肿瘤, 基因, p53, 输卵管, 肿瘤, 腺和上皮

Abstract: It is difficulty for early detection of epithelial ovarian cancer, which lead to a high fatality rate.
Effective early screening or treatment should be based on a detailed understanding of disease pathogenesis. The traditional view of ovarian cancer asserts that all tumor subtypes share a common origin in ovarian surface epithelium, but it has limitation. Fallopian tube as a site of origin may have been answered by a series of studies investigating the prevalence of occult fallopian tube cancer in women with germline BRCA gene mutations. We study ovarian surface epithelium and cortical inclusion cysts, two-pathway model and fallopian tube as a site of origin in order to help the early diagnosis and therapy of epithelial ovarian cancer.

Key words: Ovarian neoplasms, Genes, p53, Fallopian tubes, Neoplasms, glandular and epithelial