国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 340-343.

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DNA甲基化及其新进展

陶 冶, 王 勇   

  1. <SPAN lang=EN-US style=
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15
  • 通讯作者: 王 勇

DNA Methylation and Its Progress

TAO Ye, WANG Yong   

  1. Histology and Embryology Teaching and Research Section, Medical School of Nanjing University, Nanjing 210093, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15
  • Contact: WANG Yong

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被引次数

50

摘要： 表观遗传是一种没有DNA序列变化并且可以遗传的基因功能变化。甲基化是表遗传修饰的一种重要形式，是基因型和表型间的重要纽带。DNA甲基化受到DNA甲基化转移酶的调控，并在细胞增殖分化的过程中，将基因的甲基化状态遗传给后代。真核生物DNA甲基化的差异，在基因表达的调节过程中以多种形式起着重要作用。随着DNA甲基化研究方法的不断发展和进步，人类正加快探索DNA甲基化的奥秘。DNA甲基化在肿瘤等疾病的研究中取得进展。甲基化已成为生物学研究的热点。

关键词: DNA甲基化, 基因表达, 肿瘤, 干细胞

Abstract: Epigenetics is a heritable alteration of the genetic function without an alteration in DNA sequence. Methylation is one of the most cardinal forms of epigenetic modification, which is a tie between genotype and phenotype. Under the regulation of DNA methyltransferases, DNA methylation hands down by heredity during the proliferation and differentiation of cells. The difference of DNA methylation in eukaryote plays a significant role in the regulation of gene expression in different ways. Nowadays, with the help of the development in the research technique of DNA methylation, humans are manding the pace in exploring DNA methylation. Pleasant progress has come out especially in the research of some diseases such as cancer. Actually, DNA methylation has become a hotspot in the field of Biology.

Key words: DNA methylation, Gene expression, Neoplasms, Stem cells