国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (5): 347-350.

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子宫内膜干细胞在子宫内膜异位症发病中意义

袁 华, 龚 健   

  1. <SPAN lang=EN-US style=
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-10-15 发布日期:2010-10-15

Research of Endometrial Stem Cells and Its Significance in the Pathogenesis of Endometriosis

YUAN Hua, GONG Jian   

  1. Department of Obstetrics and Gynecology, Wuxi Maternal and Child Health Hospital, Nanjing Medical University, Wuxi 214002, China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-10-15 Online:2010-10-15

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摘要： 子宫内膜异位症（EMs）发病是多因素的。越来越多的研究尝试着分离并界定出人类子宫内膜干/祖细胞，且这些干细胞可能定位于基底层的间质中。目前仍未找到独特的鉴定子宫内膜干细胞的标志物。子宫内膜可能存在至少两种干细胞，包括子宫来源或骨髓来源的干细胞，其可经逆流的经血或经循环迁移至异地，并在特定的微环境中形成EMs病灶，这表明EMs可能是一种干细胞疾病。

关键词: 子宫内膜异位症, 干细胞, 子宫内膜, 细胞分化

Abstract: The pathogenesis of endometriosis is multifactorial. More and more studies attempt to isolate and characterize endometrial stem/progenitor cells. These stem cells possibly reside in the stromal of the basal layer. Currently, no known markers are specific for the endometrial stem/progenitor cells. There are perhaps at least two endometrial stem cells, including endometrium-derived and bone marrow-derived stem cells, which likely migrate to ectopic sites through retrograde menstrual flow or via the circulation and form endometriotic implants in specific microenvironment. It shows that endometriosis maybe a stem cell disease.

Key words: Endometriosis, Stem cells, Endometrium, Cell differentiation