国际妇产科学杂志

国际妇产科学杂志 ›› 2010, Vol. 37 ›› Issue (6): 420-422.

• 综述 • 上一篇    下一篇

多倍体细胞与肿瘤关系的研究进展

王 彦， 袁碧波 ，岳天孚   

  1. 300052　天津医科大学总医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-12-15 发布日期:2010-12-15
  • 通讯作者: 岳天孚

Research Progress of Polyploidy and Cancer

WANG Yan，YUAN Bi-bo，YUE Tian-fu   

  1. Department of Obstetrics and Gynecology，General Hospital of Tianjin Medical University，Tianjin 300052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2010-12-15 Online:2010-12-15
  • Contact: YUE Tian-fu

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摘要： 多倍体常见于高等植物，动物界极少发生。人类DNA多倍体是染色体异常的表型，也是细胞癌变的特征指标，与恶性肿瘤的异常增殖相关。细胞周期有丝分裂监控点、中心体异常和胞质分裂异常等均可形成多倍体细胞，这类细胞具有高度染色体不稳定性，可能更容易表现遗传变化导致转变，并最终形成肿瘤。

关键词: 染色体畸变, 肿瘤, 基因, 非整倍体, 多倍体

Abstract: Polyploidy is commonly observed in higher plants，animals seldom occur. DNA polyploidy is phenotype of chromosome abnormality，also is the cell canceration characteristic target，and correlated with the malignant tumor exceptionally multiplication. Polyploidy is influnced by a intact spindle assembly checkpoint，abnormole of centrosome and cytokinesis，these cells have high chromosome instability，genetic instability in polyploid cells，are more likely to show genetic changes that lead to change，and eventually the formation of tumors.

Key words: Chromosome aberrations, Neoplasms, Genes, Aneuploidy, Polyploidy