国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (3): 207-210.

• 综述 • 上一篇    下一篇

绒毛膜羊膜炎诊断的研究进展

赵志英,杨玲竹   

  1. 450052 郑州大学第一附属医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-06-15 发布日期:2011-06-15
  • 通讯作者: 杨玲竹

Progress in Study on Diagnosis of Chorioamnionitis

ZHAO Zhi-ying，YANG Ling-zhu   

  1. Department of Obstetrics and Gynecology，the First Affiliated Hospital of Zhengzhou University，Zhengzhou 450052，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-06-15 Online:2011-06-15
  • Contact: YANG Ling-zhu

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5507

被引次数

29

摘要： 绒毛膜羊膜炎多继发于未足月胎膜早破，与早产关系密切。因为早产是3/4以上新生儿死亡的直接原因，故应高度警惕绒毛膜羊膜炎的发生，尤其是亚临床绒毛膜羊膜炎易被忽略。大量文献分别研究了传统生物指标包括红细胞沉降率、白细胞计数、C-反应蛋白，及近代分子生物指标包括基质金属蛋白酶、白细胞介素和肿瘤坏死因子等对绒毛膜羊膜炎的诊断价值。对于早期预测亚临床绒毛膜羊膜炎，检测妊娠妇女血清的生物指标具有相对无创、精确及快捷的优点，受到越来越多临床工作者的认可。随着炎性细胞因子研究的进展，检测相关血清指标有望成为临床可靠易行的早期诊断依据。

关键词: 绒毛膜羊膜炎, 胎膜早破, 早产, 诊断, 细胞因子类

Abstract: Most chorioamnionitis is due to preterm premature rupture of membranes and is closely associated with preterm labor which induces three quarters of newnatal death.So we should pay intensive attention to the presence of chorioamnionitis，especially asymptomatic patients that is often neglected. Based on a large amount of literature， We can see the result about predictive value of chorioamnionitis from tradition bioindicator including erythrocyte sedimentation rate，white blood cell counting and the C-response protein，and from the modern molecular bioindicator including matrix metal proteinase，interleukin，tumor necrosis factor and so on.Serum bioindicators have the advantages of precision，fast and relatively noninvasive method，which is well documented in pregnants by present researchs. By the study of inflammatory cytokines，it is expected to offer new sensitive and available serum biomarkers for the prospective diagnosis of chorioamnionitis.

Key words: Chorioamnionitis, Fetal membranes, premature rupture, Premature birth, Diagnosis, Cytokines