国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (4): 316-319.

• 综述 • 上一篇    下一篇

水通道蛋白及其与子宫内膜癌的关系

牟 田,王建六   

  1. 100044 北京大学人民医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-08-15 发布日期:2011-08-15

Reviews on Aquaporins and Its Relationship with Endometrial Cancer

MU Tian, WANG Jian-liu   

  1. Department of Obstetrics and Gynecology， Peking University People′s Hospital， Beijing 100044， China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-08-15 Online:2011-08-15

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摘要： 水通道蛋白（AQPs）是一组小分子跨膜蛋白家族，对水分子有高度通透性，表达谱广泛，且参与细胞的水代谢。子宫内膜癌是妇科发病率最高的恶性肿瘤之一，最常见的病理类型是子宫内膜腺癌，其发病与长期雌激素的刺激相关，但子宫内膜腺癌发生发展的分子机制尚未完全阐明。AQPs可通过促进细胞生长、血管新生、细胞迁移几个方面影响肿瘤的生长和发展，AQPs在子宫内膜癌中表达上调，参与子宫内膜癌血管新生，并与子宫内膜癌分期分级等临床病理特征存在相关性。

关键词: 水孔蛋白质类, 子宫内膜肿瘤, 雌激素类, 肿瘤侵润

Abstract: The aquaporins are family of small membrane-spanning proteins which have high permeability for water molecule that are expressed at plasma membranes in many cells types involved in fluid transprot. Endometrial cancer is the highest incidence of gynecological malignant tumor， and the endometrial adenocarcinoma is the most common histological type. Long-term estrogen stimulation is one of the causes of the cancer. But the molecular mechanism has not been fully elucidated. AQPs can promote cell growth， angiogenesis， and cell migration, potentially facilitating tumor growth and metastasis. AQPs were overexpressed in endometrial cancer and have certein relationship with the clinicopathological features.

Key words: Aquaporins, Endometrial neoplasms, Estrogens, Neoplasm invasiveness