国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 390-393.

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Toll样受体在母胎界面的表达与早产的关系


刘 蓉, 黄 坚   

  1. 310006 杭州市第一人民医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 黄 坚

The Research Progress of Toll-like Receptors at the Maternal-fetal Interface and the Relationship with Preterm Labor

LIU Rong，HUANG Jian   

  1. The First People’s Hospital of Hangzhou，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: HUANG Jian

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被引次数

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摘要： 早产严重危及围生儿的生命及预后，宫内感染是导致早产的重要原因之一。Toll样受体（TLRs）是固有免疫系统中重要的病原模式识别受体，可调控适应性免疫应答，在母胎界面有广泛表达。TLRs参与母胎界面的炎症反应应答，保护胎儿免受外源性病原微生物感染，同时介导母儿间的免疫耐受。近来众多研究发现，感染导致的TLRs表达失调与早产的发生有一定的相关性。综述TLRs在胎盘、羊膜、蜕膜上的表达及其在早产中可能的作用机制。

关键词: Toll样受体, 早产, 炎症, 胎盘

Abstract: Preterm labor endanger perinatal health and pregnancy complications. Infection has been recognized to be closely related to the occurrence of preterm labor. Toll-like receptors （TLRs） form the major family of pattern recognition receptors（PRR） that are involved in innate immunity and regulating adaptive immunization. TLRs is found to be expressed on maternal-fetal interface widely. TLRs take part in immunological reaction on maternal-fetal interface，protecting the fetus from infection of pathogenic microorganism and mediating the immune tolerance between maternal and fetal. There are increasing investigates adout the relationship of disorderd action of TLRs and preterm labor. The expression of TLRs in placenta，amniotic and decidua and its possible mechanism of action in preterm labor are reviewed in this paper.

Key words: Toll-like receptors, Premature birth, Inflammation, Placenta