国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (5): 407-410.

• 综述 • 上一篇    下一篇

多囊卵巢综合征胰岛素抵抗新进展

沈文娟, 匡洪影, 张跃辉,吴效科,侯丽辉   

  1. 150040 哈尔滨,黑龙江中医药大学附属第一医院 妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-10-15 发布日期:2011-10-15
  • 通讯作者: 吴效科

Molecular Mechanism and Management in Insulin Resistance in Polycystic Ovary Syndrome

SHEN Wen-juan，KUANG Hong-ying，ZHANG Yue-hui，WU Xiao-ke，HOU Li-hui   

  1. Department of Gynecology and Obstetrics，First Affiliated Hospital，Heilongjiang University of Chinese Medicine，Harbin 150040，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-10-15 Online:2011-10-15
  • Contact: WU Xiao-ke

PDF (PC)

4856

被引次数

19

摘要：
多囊卵巢综合征（PCOS）是一种常见的影响育龄期女性生殖和内分泌功能的特殊疾病，其临床表现异质性，以慢性无排卵、卵巢多囊样改变、高雄激素血症为主要临床表现。胰岛素抵抗是其发生、发展的重要病理生理机制之一，也是导致高雄激素血症和卵巢功能改变的重要原因。近年来，PCOS患者胰岛素抵抗的分子机制得到深入研究，为临床治疗提供了理论依据。综述PCOS胰岛素抵抗的分子机制研究和药物治疗进展。

关键词: 多囊卵巢综合征, 胰岛素抗药性, 高胰岛素血症, 葡萄糖钳制技术, 二甲双胍

Abstract: Polycystic ovary syndrome（PCOS）is one of the most common endocrine disorder with a variety of clinical manifestations among women of reproductive age. Its features include chronic anovulation，multicystic morphology of ovaries，hyperandrogenism. In recent years，insulin resistance（IR）has been regarded as one of the mechanisms of the development of PCOS，and is also associated with the hyperandrogenemia and dysfunction of ovaries. Many researches have been done on the molecular mechanism of IR in PCOS，which might provide a theory foundation for the treatment. This review thus focuses on the molecular mechanism and treatment of insulin resistance in patients with PCOS.

Key words: Polycystic ovary syndrome, Insulin resistance, Hyperinsulinism, Glucose clamp technique, Metformin