国际妇产科学杂志

国际妇产科学杂志 ›› 2011, Vol. 38 ›› Issue (6): 578-580.

• 论著 • 上一篇    下一篇

抗苗勒管激素用于多囊卵巢综合征诊断的探讨

张 芳 , 王建   

  1. 410008 长沙,湖南省妇幼保健院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2011-12-15 发布日期:2011-12-15

Study of Sersum Anti-mullerian Hormone as Marker for Diagnosis of Polycystic Ovary Syndrome

ZHANG Fang，WANG Jian-hui   

  1. he Maternal Hospital of Hunan Province，Changsha 410008，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2011-12-15 Online:2011-12-15

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摘要： 目的：探讨抗苗勒管激素（AMH）在多囊卵巢综合征（PCOS）诊断的应用价值。方法：用电化学免疫发光法检测75例PCOS患者（研究组）及86例正常排卵育龄妇女（对照组）月经第2日内分泌水平，酶联免疫吸附法（ELISA）检测血清AMH，同时应用超声诊断仪行卵巢卵泡计数（FN）。结果：①研究组与对照组血清AMH水平分别为（8.21±2.32） mg/L和（2.39±1.29） mg/L ，研究组AMH水平明显高于对照组。②研究组AMH与FN、睾酮（T）、黄体生成激素（LH）、LH/FSH呈正相关（r分别为0.489，0.215，0.312和0.256，均P＜0.05），而与卵泡刺激素（FSH）、雌二醇（E2）、泌乳素（PRL）、体质量指数（BMI）无线性相关性（r分别为0.12，0.19，0.10和0.16，均P＞0.05）。结论：AMH用于临床PCOS诊断有一定价值，且简便易行。

关键词: 抗苗勒管激素, 多囊卵巢综合征, 卵泡刺激素, 雌二醇, 睾酮

Abstract: Objective：To explore whether anti-mullerian hormone（AMH） measurement in the serum could be a marker for diagnosis of polycystic ovary syndrome（PCOS）. Methods：Serum AMH was measured with immunoassay in a cohort of 75 PCOS patients and 86 controls，and follicle number was estimated by ultrasound scanning. Results：Serum AMH levels were 4-fold higher in PCOS patients than in control group［（8.21±2.32） mg/L vs.（2.39±1.29） mg/L］，and were significantly related to the follicle number in the two groups. In PCOS patients，AMH concentrations correlated with the number of ovarian follicles、testosterone、LH and LH/FSH（r= 0.489，0.215，0.312 and 0.256，P＜0.05），but not related with FSH、E2 PRL and BMI（r=0.12，0.19，0.10 and 0.16，P＞0.05）.Conclusions：The serum AMH level was a marker which may be used for diagnosis of the PCOS.

Key words: Anti-mullerian hormone, Polycystic ovary syndrome, Follicle stimulating hormone, Estradiol, Testosterone