国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 220-223.

• 综述 • 上一篇    下一篇

环氧合酶-2与子宫内膜异位症相关性的研究进展

孙艳美 ,张信美   

  1. 310006 杭州,浙江大学医学院附属妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15
  • 通讯作者: 张信美

Recent Progress of Cyclooxygenase-2 in the Pathogenesis of Endometriosis

SUN Yan-mei，ZHANG Xin-mei   

  1. Women’s Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15
  • Contact: ZHANG Xin-mei

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摘要： 子宫内膜异位症是一种妇科常见病，至今其发病机制仍不清楚。近年研究发现，环氧合酶2（COX-2）在子宫内膜异位症的在位和异位内膜表达增高，与该病密切相关。COX-2可通过抑制细胞凋亡途径促进子宫内膜异位病灶的生长，主要是通过调节抗凋亡蛋白和促凋亡酶的表达来起作用；COX-2还可通过血管生成途径促进异位子宫内膜细胞增殖生长，这种作用是基于提高促血管生成因子的表达来实现的。就近年来COX-2与子宫内膜异位症相关性的研究进展作一综述。

关键词: 子宫内膜异位症, 前列腺素内过氧化物合酶类, 血管生成诱导剂, 雌激素类

Abstract: Causes of endometriosis remains unclear up to date，although it is a common benign disease in gynecologic clinic. Recent studies have shown that cyclooxygenase-2（COX-2） plays an important role in endometriosis，which exhibits an increasing expression in eutopic and ectopic endometrium. COX-2 can suppress apoptosis pathway of endometrial cells to promote the growth of endometriotic lesion by regulating the expression of anti-apoptotic proteins and pro-apoptotic enzymes；COX-2 can also facilitate angiogenesis to support the growth and proliferation of endometriotic cells，which is based on the increased expression of angiogenic factors. This article made an review of the role of COX-2 in pathogenesis of endometriosis.

Key words: Endometriosis, Prostaglandin-endoperoxide synthases, Angiogenesis inducing agents, Estrogens