国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (3): 243-246.

• 综述 • 上一篇    下一篇

卵巢癌动物模型研究进展

孙 玮,傅士龙   

  1. 210029 南京医科大学第一附属医院妇科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-15 发布日期:2012-06-15

The Progress of Animal Models of Ovarian Carcinoma

SUN Wei，FU Shi-long   

  1. Department of Gynecology，the First Affliated Hospital of Nanjing Medical University，Nanjing 210029，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-06-15 Online:2012-06-15

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4918

被引次数

3

摘要： 卵巢癌是女性最常见的妇科恶性肿瘤之一，卵巢癌动物模型包括：自发瘤模型、异种移植瘤模型、化学药物诱导肿瘤模型以及基因工程改造模型等。随着基因工程小鼠（GEM）、同基因型肿瘤模型、异种移植瘤模型以及活体动物体内成像技术的应用，使得这一类临床前研究变得更加完善。卵巢癌动物模型的建立有助于更好地探索卵巢癌的本质，探讨卵巢癌的发生、发展规律及探索新的、有效的卵巢癌治疗方案。

关键词: 卵巢肿瘤, 疾病模型, 动物, 肿瘤移植, 小鼠, SCID, 小鼠, 转基因, 小鼠, 基因敲除

Abstract: Ovarian carcinoma is one of the most common and lethal gynecological malignancies. This review describes some of the experimental animal models of ovarian carcinoma，including spontaneous，xenografted， chemically induced and genetically engineered models.Consideration has also been given to the recent progress in modeling ovarian cancer using spontaneous and induced ovarian surface epithelium transformation. Animal models which accurately represent the cellular and molecular changes associated with the initiation and progression of human ovarian cancer have significant potential to facilitate the development of better detection and treatment.

Key words: Ovarian neoplasms, Disease models, animal, Neoplasm transplantation, Mice, SCID, transgenic, Mice, knockout