国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 581-584.

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微小RNA与病理妊娠的研究进展

黄 璐, 沈宗姬 , 李德春   

  1. 215006 江苏省苏州市,苏州大学附属第一医院普外科(黄 璐,李德春);苏州大学附属第一医院妇产科(沈宗姬);南京医科大学附属无锡妇幼保健院(黄 璐)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 李德春

The Study Advancement of the MicroRNAs and Obstetric Pathologies

HUANG Lu，SHEN Zong-ji，LI De-chun   

  1. Department of General Surgery，the First Affiliated Hospital of Soochow University，Suzhou 215006，Jiangsu Province，China（HUANG Lu，LI De-chun）；Department of Obstetrics and Gynecology，the First Affiliated Hospital of Suzhou University， Suzhou 215006，Jiangsu Province，China（SHEN Zong-ji）；Wuxi Maternity and Child Care Hospital Affliated to Nanjing Medical University，Wuxi 214002，Jiangsu Province，China（HUANG Lu）
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15
  • Contact: LI De-chun

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摘要： 微小RNAs（microRNAs，miRNAs）是一类内源性17～25个核苷酸大小的非编码RNA分子，精确调节神经元及其他细胞的发育、分化、增殖、凋亡以及参与免疫调控、神经元可塑性及信号传导过程中miRNAs转录后处理重抑制效应而增加基因表达。研究表明，miRNAs参与生命过程中一系列的重要进程，胎儿发育和妊娠病理结局受到不连续的差异性表达miRNAs的调控。miRNAs的表达水平变化与胎儿生长受限、胎膜早破、子痫前期和巨大儿等妊娠病理结局密切相关。

关键词: 微RNAs, 基因调控网络, 先兆子痫, 胎儿生长迟缓

Abstract: MicroRNAs （miRNAs） are a class of endogenous non-coding small RNAs with length range of 17-25
nucleotides（nt），which are the most widely studied， and highly conserved in many processes of biological evolution. which play a role in precisely regulating the development，differentiation，proliferation and apoptosis of neurons and other kinds of cell，and involved in immune regulation，neuronal plasticity and re-inhibitory effect of mRNA post-transcriptional processing of signal transduction pathways to increase gene expression. The study indicate that miRNAs participate the important vital process，including fetal development and pregnancy pathological outcome.They receive the differential expression of miRNAs regulation. The level of miRNAs expression have close correlated with pregnancy pathological outcome，including fetal growth retardation，premature rupture of membrane，pre-eclampsia and macrosomia.

Key words: MicroRNAs, Gene regulatory networks, Pre-eclampsia, Fetal growth retardation