国际妇产科学杂志

国际妇产科学杂志 ›› 2012, Vol. 39 ›› Issue (6): 624-626.

• 综述 • 上一篇    

纳米级载药系统在卵巢癌治疗中的研究进展

王云飞, 狄 文   

  1. 200127 上海交通大学医学院附属仁济医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-12-15 发布日期:2012-12-15
  • 通讯作者: 狄 文

Advances on Nanoscale Drug Delivery System in the Treatment of Ovarian Cancer

WANG Yun-fei，DI Wen   

  1. Department of Obstetrics and Gynecology，Renji Hospital，School of Medicine，Shanghai Jiaotong University，Shanghai 200127，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2012-12-15 Online:2012-12-15
  • Contact: DI Wen

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摘要： 卵巢癌是妇科肿瘤中恶性程度最高的疾病，早期不易发现，病死率高。其治疗主要是以手术、化疗为主的综合治疗。纳米级载药系统具有很好的缓释性、靶向性等诸多优点，能提高对肿瘤细胞的杀伤作用而不影响正常细胞，在肿瘤的治疗中显现出很好的抗瘤效果，是治疗卵巢癌的一种新手段和目前研究的热点，如主动和被动靶向纳米载药、载基因及磁性纳米粒等。整理分析近年国内外有关纳米级载药系统的相关文献，介绍其在卵巢癌治疗中的研究进展。

关键词: 卵巢肿瘤, 纳米结构, 纳米技术, 药物载体, 药物释放系统, 抗肿瘤药

Abstract: Ovarian cancer is the highest malignancy among gynecologic cancer. It holds high mortality because most
patients are diagnosed at advanced stages. Surgery and chemotherapy are the primarily treatments for patients. Nanoscale drug delivery system has a good slow release，targeting，and many other advantages，which can enhance the killing effect on tumor cells without affecting normal cells. Nanoscale drug delivery system is a new means and a hot research in current，showing a good anti-tumor effect in the treatment of tumors，such as active and passive targeting，loading drug or gene nanoparticles，magnetic nanoparticles. In this paper，studies about nano-drug delivery system in the field of ovarian carcinoma are reviewed

Key words: Ovarian neoplasms, Nanostructures, Nanotechnology, Drug carriers, Drug delivery systems, Antineoplastic agents