国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (2): 152-155.

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极化型肿瘤相关巨噬细胞及其与卵巢癌的相关性

张洪秀， 陈 燕， 金 平   

  1. 730001兰州大学第一临床医学院（张洪秀，陈燕）；兰州军区兰州总医院（张洪秀）；深圳市妇幼保健院（金平）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-04-15 发布日期:2013-04-15
  • 通讯作者: 金 平

Development of Relativity between M2-Tumor Associated Macrophage and Ovarian Cancer

ZHANG Hong-xiu，CHEN Yan，JIN Ping   

  1. The First Clinical College of Lanzhou University，Lanzhou 730001，China（ZHANG Hong-xiu，CHEN Yan）；The General Hospital of Lanzhou Military Area，Lanzhou 730050，China（ZHANG Hong-xiu）；Shenzhen Maternity and Child Healthcare Hospital，Shenzhen 518000，Guangdong Province，China（JIN Ping）
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-04-15 Online:2013-04-15
  • Contact: JIN Ping

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5117

被引次数

6

摘要： 肿瘤相关巨噬细胞（TAM）与肿瘤发生发展的关系一直以来都是肿瘤的病因及治疗的研究热点，实验及临床研究表明不同类型肿瘤的发生发展与TAM有密切关系。TAM是参与肿瘤相关性炎症的重要调节细胞，而在肿瘤微环境中表现促肿瘤生长的亚型主要为极化型（M2-TAM）。M2-TAM通过趋化因子18（CCL-18）、血管内皮生长因子（VEGF）和基质金属蛋白酶9（MMP-9）等抑制T细胞的抗肿瘤活性并促进血管生成。因此，M2-TAM在肿瘤组织中的浸润情况可能是肿瘤发生、发展、转移及判断预后的一个重要指标，并为卵巢癌的治疗提供新的途径。综述M2-TAM在卵巢癌发生发展中的重要作用，并为卵巢癌的治疗及早期诊断提供新的方向。

关键词: 卵巢肿瘤, 巨噬细胞, 肿瘤逃逸, 极化型肿瘤相关巨噬细胞

Abstract: Tumor-related inflammation including lymphocyte infiltration into tumor tissue. Tumor-associated macrophages（TAM） are important regulator of cells，mainly involved in tumor-associated inflammatory. While M2-tumor associated macrophage is the main subtype macrophages which expression in the tumor microenvironment，promote and coordinate neoplastic growth. M2-type TAM inhibite the anti-tumor activity of T cells and promote angiogenesis by over expressing CCL-18，VEGF，and MMP-9. M2-type TAM infiltration in tumor tissue might be an important indicator of tumor development，metastasis and prognosis，and providing a new approach to treatment of ovarian cancer. Polarization-type tumor-associated macrophages play an important role in the development of ovarian cancer and provide a new direction in early diagnosis and treatment of ovarian cancer .

Key words: Ovarian neoplasms, Macrophages, Tumor escape, M2-tumor associated macrophage