国际妇产科学杂志

国际妇产科学杂志 ›› 2013, Vol. 40 ›› Issue (5): 420-423.

• 综述 • 上一篇    下一篇

荧光原位杂交技术在产科相关领域的应用

游艳琴,李亚里   

  1. 100853 北京，中国人民解放军总医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2013-10-15 发布日期:2013-10-15

The Application of Fluorescence in Situ Hybridization in Correlative Obstetric Field

YOU Yan-qin，LI Ya-li   

  1. Department of Obstetrics and Gynecology，Chinese PLA General Hospital，Beijing 100853，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2013-10-15 Online:2013-10-15

PDF (PC)

4813

被引次数

1

摘要： 荧光原位杂交（fluorescence in situ hybridization，FISH）技术是20世纪80年代末在放射性原位杂交技术基础上发展起来的一种非放射性分子细胞遗传技术，其是分子生物学、细胞遗传学及免疫学技术相结合的产物。该技术已广泛应用于分子生物学、医学、细胞遗传学等诸多领域，在产科已用于胚胎植入前遗传学诊断、产前诊断、自然流产和胎儿先天性心脏病的研究。综述FISH技术在产科相关领域的应用。

关键词: 原位杂交, 荧光, 植入前诊断, 产前诊断, 流产, 自然, 心脏缺损, 先天性

Abstract: Fluorescence in situ hybridization is a new non-radioactivity molecular cytogenetic technique based on radioactivity in situ hybridization since 1980. It′s a production combined with molecular biology，cytogenetics and immunology. This technique is applied broadly in molecular biology，medicine，cytogenetics and so on. It has been applied in the study of preimplantation genetic diagnosis，prenatal diagnosis，spontaneous abortion and congenital heart diseases. This review give a brief overview of its application in obstetric field.

Key words: In situ hybridization, fluorescence, Preimplantation diagnosis, Prenatal diagnosis, Abortion, spontaneous, congenital