国际妇产科学杂志

国际妇产科学杂志 ›› 2014, Vol. 41 ›› Issue (2): 103-107.

• 综述 • 上一篇    下一篇

细胞凋亡途径及其机制

李敏，林俊   

  1. 310006 杭州，浙江大学医学院附属妇产科医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2014-04-15 发布日期:2014-04-15

The Apoptotic Pathways and Their Mechanisms

LI Min，LIN Jun   

  1. Department of Obstetrics and Gynecology，Women′s Hospital，School of Medicine，Zhejiang University，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2014-04-15 Online:2014-04-15

PDF (PC)

7843

被引次数

125

摘要： 细胞凋亡存在于多细胞生物的整个生命过程当中，可及时清除机体内多余和受损伤的细胞，维持组织器官的稳定性。真核细胞主要通过死亡受体介导的外部凋亡途径、内部线粒体途径、B粒酶介导的细胞凋亡途径以及近几年开始关注的内质网应激途径介导细胞凋亡的发生。而参与这些细胞凋亡过程的主要有4类蛋白分子，即凋亡蛋白酶（caspases）、衔接蛋白（adapter proteins）、Bcl-2和凋亡抑制蛋白（IAPs）。细胞凋亡对卵巢储备及一些妇科疾病如子宫内膜异位症、卵巢癌等的发生发展产生影响。

关键词: 细胞凋亡, 凋亡蛋白酶活化因子1, 衔接蛋白类, 信号转导, 基因, bcl-2, 凋亡抑制蛋白类

Abstract: Cell apoptosis exists in the whole life of multicellular organisms，which is capable to maintain homeostasis of tissues and organs through removing unwanted or damaged cells. Eukaryotic cells mediate apoptosis through four main pathways：the death receptor-mediated extrinsic pathway，the intrinsic mitochondrial pathway，granzyme B-mediated pathway and endoplasmic reticulum stress-mediated pathway. There are four important protein molecules involved in apoptotic pathways：caspases （the proteases which execute cell death），adapter proteins （caspase activators），Bcl-2 family proteins and Inhibitor of apoptosis proteins（IAPs）. Cell apoptosis plays an important role in establishment of ovarian reserve and abnormal apoptosis inducing some diseases，such as endometriosis，ovarian cancer，et al. In this review we will discuss the apoptotic pathways and their mechanisms mentioned above.

Key words: Apoptosis, Apoptotic protease-activating factor 1, Adaptor proteins, signal transducing, Genes, bcl-2