国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (1): 91-95.

• 综述 • 上一篇    下一篇

死亡结构域相关蛋白及其在宫颈病变中的研究进展

周蕾，张淑兰   

  1. 110004 沈阳，中国医科大学附属盛京医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-02-15 发布日期:2015-02-15
  • 通讯作者: 张淑兰

Research Progress of Death Domain Associated Protein and Its Related Research in Cervical Lesions

ZHOU Lei，ZHANG Shu-lan   

  1. Department of Obstetrics and Gynecology，Shengjing Hospital of China Medical University，Shenyang 110004，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-02-15 Online:2015-02-15
  • Contact: ZHANG Shu-lan

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摘要： 宫颈癌对妇女健康构成严重威胁，人乳头瘤病毒感染与宫颈病变及宫颈癌的发生密切相关。关于宫颈癌发生发展的机制仍在研究中。近年研究发现一种多功能核蛋白，即死亡结构域相关蛋白（death domain associated protein，Daxx），其与细胞内蛋白或病毒蛋白相互作用，参与调节细胞凋亡、转录调控、抗病毒等细胞活动，在不同途径中发挥不同的生理或病理作用。通过对Daxx功能及其作用机制的研究有助于进一步阐明宫颈癌发生发展的机制，有助于发现新的预防和治疗方法。综述Daxx的一般特性和研究现况及其在宫颈病变的研究进展。

关键词: 死亡结构域相关蛋白, 宫颈疾病, 乳头状瘤病毒科, 细胞凋亡, 转录因子

Abstract: Cervical cancer seriously threat the health of women，and human papillomavirus is closely related with cervical lesions and cervical cancer. People are striving to find the mechanism of the occurrence and development of cervical cancer.Recent years，studies indicate that a multi-functional nucleoprotein， death domain associated protein （Daxx） has been found.Daxx may interact with proteins in cells or viral proteins，and be involved in cell activities such as regulating cell apoptosis， transcription regulating or antiviral. It plays different roles in physiologically or pathologically through different pathways. Research the function and mechanism of Daxx can expand our knowledge of the origin and development mechanism of cervical cancer，which is helpful to find new methods of prevention and treatment. This paper reviews the biological characteristics and the current states of Daxx，and research progress on Daxx in cervical lesions.

Key words: Death domain associated protein, Uterine cervical diseases, Papillomaviridae, Apoptosis, Transcription factors