国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (4): 387-389.

• 论著 • 上一篇    下一篇

甲状腺自身抗体与复发性流产相关性的研究

程兰   

  1. 300100 天津市中心妇产科医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 程兰

Study of the Relationship between Thyroid Autoantibodies and Recurrent Spontaneous Abortion

CHENG Lan   

  1. Tianjin Central Hospital of Gynecology Obstetrics，Tianjin 300100，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-15 Online:2015-08-15
  • Contact: CHENG Lan

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摘要： 目的：探讨甲状腺自身抗体（ATA）与复发性流产的相关性。方法：收集2013年8月—2014年4月于我院产科进行孕前检查，并符合入组条件的非妊娠期妇女，其中有复发性流产病史妇女92例，夫妻双方染色体检查未见异常，凝血功能相关检查无异常，为研究组；无复发性流产病史妇女226例，为对照组。检测2组对象甲状腺球蛋白抗体（ＴｇＡｂ）和甲状腺过氧化物酶抗体（ＴＰＯＡｂ） 的阳性率， ＴｇＡｂ（＋）和（或）ＴＰＯＡｂ（＋）为ＡＴＡ阳性。结果：①研究组中，年龄≥３５岁及＜35岁者的ATA阳性率分别为39.29%（11/28）和26.56%（17/64），差异无统计学意义（P＞0.05）；在对照组中则分别为25.00%（10/40）和18.28%（34/186），差异也无统计学意义（P＞0.05），说明ATA在不同年龄阶段的状况相近。②研究组ATA阳性率为30.43%（28/92），高于对照组的19.47%（44/226），差异有统计学意义（P＜0.05）。研究组TPOAb阳性率为30.43%（28/92），高于对照组的11.95%（27/226），差异有统计学意义（P＜0.05）。研究组TgAb阳性率为7.61%（7/92），与对照组的7.52%（17/226）比较差异无统计学意义（P＞0.05）。结论：ATA与复发性流产有关，尤其与TPOAb关系密切。

关键词: 流产, 习惯性, 甲状腺球蛋白, 碘化物过氧化物酶, 甲状腺自身抗体

Abstract: Objective：To investigate the relationship between antithyroid antibodies（ATA） and recurrent spontaneous abortion（RSA）. Methods：Collected the women undergoing the examinations before pregnancy in out-patient department from August 2013 to March 2014，and according with the criterion had made for the study. 92 women had RSA history were in the study group，and their chromosome and coagulation function tests were normal. 226 women without RSA history were in the control group. TgAb(+) and/or TPOAb(+) suggested ATA(+)。Results：① In study group，the position rate of ATA in 35 years old and above women and younger than 35 years old was 39.29%（11/28） and 26.56%（17/64） respectively. There was no statistical significance（P＞0.05）. And in control group was 25.00%（10/40） and 18.28%（34/186） respectively, no statistical significance（P＞0.05）. So we thought ATA positive rate in different age stage was similar.② ATA positive rate was 30.43%（28/92） in study group，higher than the control′s 19.47%（44/226），the difference had statistical significance（P＜0.05）. TPOAb positive rate in study and control group was 30.43%（28/92） and 11.95%（27/226），the difference had statistical significance（P＜0.05）. TgAb positive rate was 7.61%（7/92）in the study group，although it was higher than the control 7.52%（17/226），but no statistical significance（P＞0.05）. Conclusions：ATA was related with RSA significantly, especially TPOAb.

Key words: Abortion, habitual, Thyroglobulin, Iodide peroxidase, Anti-thyroid antibody