国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (4): 449-452.

• 综述 • 上一篇    下一篇

长链非编码RNA与妇科肿瘤研究进展

王昕婧，汪希鹏   

  1. 200120 上海，同济大学附属第一妇婴保健院妇科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 汪希鹏

Research Progress of Long Non-coding RNA and Gynecologic Tumor

WANG Xin-jing，WANG Xi-peng   

  1. Department of Gynecology，First Maternity and Infant Hospital Affiliated to Tongji University，Shanghai 200120，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-08-15 Online:2015-08-15
  • Contact: WANG Xi-peng

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摘要： 长链非编码RNA（long non-coding RNA，lncRNA）是一类长度超过200个碱基的RNA分子。由于不参与编码形成蛋白质分子，早期观点普遍认为lncRNA分子是基因组转录过程中形成的副产物，被定义为不具备生物学功能的转录组“背景噪音”。然而，近年来越来越多的研究发现，在哺乳动物基因组中，lncRNA分子首先由数千个基因位点转录形成，随后，经过加工的成熟lncRNA分子在动物胚胎发育、基因表达调节以及疾病发生和发展中起关键性调控作用。目前已有研究证实，在多种人类肿瘤疾病中，部分特异性lncRNA分子的表达水平在疾病进展的各时期中发生显著了变化。在妇科恶性肿瘤中lncRNA分子表达变化以及lncRNA通过上下游靶向分子对疾病发生和发展的影响也有了许多报道。综述这一领域最新的研究进展。

关键词: 长链非编码RNA, 卵巢肿瘤, 宫颈肿瘤, 子宫内膜肿瘤

Abstract: Long non-coding RNA（lncRNA） is a class of RNA with the length of more than 200 bases. Previously，lncRNA molecules are generally considered as byproducts formed during the transcription of the genome，and are defined as transcriptome "background noise" without biological functions since these special RNA molecules do not participate in the encoding of certain proteins. However，in recent years，an increasing number of studies have found that thousands of genes in mammalian genomes can transcribe into lncRNA. Then，after the mature processing，lncRNA molecules play a key role in animal embryonic development，regulation of gene expression and disease progress. Present studies have confirmed that the expression levels of specific clusters of lncRNA molecules change significantly during different periods of the disease progression in a variety of human tumor diseases. In gynecological malignancies，the changes of lncRNA expression levels and its regulatory roles in the development of the disease through the upstream or downstream targeting molecules have been reports in many studies. This review conclude the latest progress of this area.

Key words: Long non-coding RNA, Ovarian neoplasms, Uterine cervical neoplasms, Endometrial neoplasms