国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 492-495.

• 综述 • 上一篇    下一篇

环氧合酶2与子宫内膜息肉关系的研究进展

张佳楠，汤小晗，卢美松   

  1. 150000 哈尔滨医科大学附属第一医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15

Research Progress of Cyclooxygenase-2 in Endometrial Polyps

ZHANG Jia-nan，TANG Xiao-han，LU Mei-song   

  1. First Affiliated Hospital of Harbin Medical University，Harbin 150000，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15

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摘要： 子宫内膜息肉（endometrial polyp）是临床上较常见的妇科疾病，可导致子宫不规则出血、月经量增多、不孕等，且有一定的恶变率。随着生殖医学及宫腔镜等技术的发展，子宫内膜息肉的诊断和治疗水平已经得到了很大的提高，但其发病机制仍不清楚。近年来的研究发现，子宫内膜息肉的发生可能是多因素作用的结果。细胞因子在子宫内膜息肉发生中的作用受到了越来越多的关注，环氧合酶2（COX-2）是前列腺素合成过程中一个主要的限速酶，可将花生四烯酸代谢成各种前列腺素及其产物。COX-2表达的调控主要在转录水平上，即细胞受到生长因子和细胞因子、脂多糖、癌基因等各种刺激，经过一系列信号转导，促进COX-2转录，从而诱导COX-2的表达，对肿瘤的发生发展有重要作用，与子宫内膜息肉的发病也密切相关。COX-2在子宫内膜息肉中的表达可能为其研究和治疗提供新的突破点。

关键词: 息肉, 子宫内膜, 环氧化酶2, 子宫内膜息肉

Abstract: Endometrial polyps (EP) is clinically more common gynecological disease that can lead to irregular uterine bleeding, increased menstrual flow, infertility, and there is a certain degree of malignant transformation rate. With the development of reproductive medicine and hysteroscopy, diagnosis and treatment of EP has been greatly improved, but the pathogenesis of EP remains unclear. Recent studies have found that the incidence of EP may be the result of multiple factors. The role of cytokines in EP is paid more and more attention. Cyclooxygenase-2 (COX-2) is a prostaglandin synthesis as a major rate-limiting enzyme in metabolism of arachidonic acid to its various prostaglandins products. COX-2 expression regulated primarily at the transcriptional level, when cells stimulated by growth factors and cytokines, lipopolysaccharides, genes and other stimulus, after a series of signal transduction, induced the COX-2 transcription and expression, which has an important role in tumor development and is closely related to onset of the EP. COX-2 expression in EP may provide a new breakthrough for the EP′s research and treatment.

Key words: Polyps, Endometrium, Cyclooxygenase 2, Endometrial polyps