国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (5): 488-491.

• 综述 • 上一篇    下一篇

端粒酶与女性生殖功能

龙娜，李瑾，蔡博宇，蔡霞   

  1. 518100 广东省深圳市，暨南大学医学院附属深圳市宝安妇幼保健院生殖健康科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-10-15 发布日期:2015-10-15
  • 通讯作者: 龙娜

Telomerase and Female Reproductive Function

LONG Na，LI Jin，CAI Bo-yu，CAI Xia   

  1. Department of Reproductive Health，Shenzhen Bao′an Maternal and Child Health Hospital，Jinan University School of Medicine，Shenzhen 518100，Guangdong Province，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-10-15 Online:2015-10-15
  • Contact: LONG Na

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摘要： 端粒酶是细胞中负责端粒延长的一种酶，通过合成染色体末端的DNA赋予细胞复制的永生性。其在保持端粒稳定、基因组完整、细胞长期的活性和潜在的继续增殖能力等方面有重要作用，端粒/端粒酶复合物的结构和功能的改变将会导致不同的疾病，尤其是癌症的发生。在人类正常生殖细胞、早期胚胎、干细胞、高度增殖体细胞和许多癌细胞中均有不同程度的端粒酶活性表达，并受到严密的调控。在女性生殖功能调控下，端粒酶活性表达在卵泡的发育及闭锁、子宫内膜的周期性变化、卵巢储备功能及性激素调节等方面发挥着重要的作用，并可在一定程度上预测卵巢储备功能及体外受精妊娠结局。

关键词: 端粒, 末端转移酶, 妇女, 生育力, 女（雌）性泌尿生殖系统疾病

Abstract: Telomerase is an enzyme which is responsible for the extension of telomeres. By synthesizing DNA ends of chromosomes, it can confer cell replication immortality, which plays an important role in maintaining telomere stability, genomic integrity, cell activity and potential long-term proliferative ability. To change the structure and function of telomere / telomerase complex behavior may result in different diseases, especially the cancer. The expression of telomerase activity has different levels in normal human germ cells, early embryos, stem cells, highly proliferative cells and many cancer cells, and telomerase activity has been shown very strict regulation. Under the regulation of female reproductive function, telomerase activity plays an important role in follicular development and atresia, cyclical changes in endometrial, ovarian reserve and regulate hormones, etc., and to a certain extent, it can predict ovarian reserve function and IVF pregnancy outcome.

Key words: Telomerase, Women, Fertility, Female urogenital diseases