国际妇产科学杂志

国际妇产科学杂志 ›› 2015, Vol. 42 ›› Issue (6): 702-704.

• 论著 • 上一篇    下一篇

胰岛素样生长因子与胎儿出生体质量的关系

李婧，陆玮玮，盛祝梅，张治芬   

  1. 310006 杭州，杭州市第一人民医院
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2015-12-15 发布日期:2015-12-15
  • 通讯作者: 张治芬

The Relationship between Insulin-like Growth Factors and Fetal Birth Weight

LI Jing，LU Wei-wei，SHENG Zhu-mei，ZHANG Zhi-fen   

  1. Hangzhou First People′s Hospital，Hangzhou 310006，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2015-12-15 Online:2015-12-15
  • Contact: ZHANG Zhi-fen

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摘要： 目的：探讨孕妇和新生儿血清胰岛素、胰岛素样生长因子Ⅰ（IGF-Ⅰ）、IGF-Ⅱ、胰岛素样生长因子结合蛋白1（IGFBP-1）、IGFBP-3与胎儿出生体质量的关系，探究胎儿生长发育的影响因子。方法：选择2012年1月—2013年2月杭州市第一人民医院住院分娩的孕妇230例，根据胎儿出生体质量与胎龄关系的分类诊断标准将胎儿出生体质量水平分为3组：小于胎龄儿（SGA）组15例，适于胎龄儿（AGA）组162例，大于胎龄儿（LGA）组53例。采用酶联免疫吸附法集中测定孕妇血清、新生儿脐血血清胰岛素、IGF-Ⅰ、IGF-Ⅱ、IGFBP-1和IGFBP-3水平。结果：3组孕妇血清和新生儿脐血血清胰岛素、IGF-Ⅰ、IGF-Ⅱ、IGFBP-3水平差异有统计学意义（均P＜0.001），LGA组大于AGA组，AGA组大于SGA组（均P＜0.01），母血血清IGF-Ⅱ和脐血血清胰岛素、IGF-Ⅰ、IGF-Ⅱ水平为胎儿出生体质量水平的影响因素。结论：母血血清IGF-Ⅱ和脐血血清胰岛素、IGF-Ⅰ、IGF-Ⅱ可能是影响胎儿生长发育的关键因子。

关键词: 胰岛素, 胰岛素样生长因子Ⅰ, 胰岛素样生长因子Ⅱ, 胰岛素样生长因子结合蛋白质1, 胰岛素样生长因子结合蛋白质3, 出生体重

Abstract: Objective：To discuss the relationship between insulin, insulin-like growth factor Ⅰ（IGF-Ⅰ）, IGF-Ⅱ, Insulin-like growth factor binding protein 1 （IGFBP-1）, IGFBP-3 in maternal blood and newborn blood and fetal birth weight. To search their influence on fetal growth and development. Methods：230 cases who gave birth in Hangzhou First People′s Hospital were selected from January 2012 to February 2013, according to the relationship between birth weight and gestational age, they were divided into 3 groups, SGA group: 15 cases who were small for gestational age infants, AGA group: 162 cases who were appropriate for gestational age infants, the LGA groups: 53 cases who were large for gestational age infants. Maternal blood and cord blood insulin, IGF-Ⅰ, IGF-Ⅱ, IGFBP-1 and IGFBP-3 levels were detected by enzyme-linked immunosorbent assay. Results：The insulin, IGF-Ⅰ, IGF- Ⅱand IGFBP-3 level in the three groups of maternal and cord blood were different（all P＜0.001）. The LGA group was higher than the AGA group, and the AGA group was also higher than the SGA group （all P＜0.01）. Maternal blood IGF-Ⅱand cord blood insulin, IGF-Ⅰ, IGF-Ⅱ can influence fetal birth weight. Conclusions：Maternal blood IGF-Ⅱand cord blood insulin, IGF-Ⅰ, IGF-Ⅱ could be the key factors which can affect fetal growth and development.

Key words: Insulin, Insulin-like growth factor Ⅰ, Insulin-like growth factor Ⅱ, Insulin-like growth factor binding protein 1, Insulin-like growth factor binding protein 3, Birth weight