国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (5): 485-488.

• 综述 •    下一篇

CD105在妇科恶性肿瘤中的应用及研究进展

王晓雨，向阳   

  1. 100730 北京，中国医学科学院 北京协和医学院 北京协和医院妇产科
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-15 发布日期:2016-10-15
  • 通讯作者: 向阳

Application and Research Progress of CD105 in Gynecological Malignant Tumors

WANG Xiao-yu，XIANG Yang   

  1. Department of Gynaecology and Obstetrics，Chinese Academy of Medical Sciences & Peking Union Medical College，Peking Union Medical College Hospital，Beijing 100730，China
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-15 Online:2016-10-15
  • Contact: XIANG Yang

PDF (PC)

5449

被引次数

2

摘要： 肿瘤血管的生成在肿瘤的生长和转移中至关重要，其可以满足肿瘤生长的代谢需要并为远处转移提供血管通路，因此被认为与肿瘤的预后密切相关。CD105又名Endoglin，是转化生长因子β（TGF-β）受体超家族的成员之一，在标记肿瘤新生血管中具有较好的特异性。近年来，CD105越来越多地应用于妇科恶性肿瘤的诊断及预后判断，其在血管内皮细胞以外的肿瘤实质及间质细胞中的作用及机制正逐步被揭示，全面了解CD105的生物学特性将为探究妇科恶性肿瘤的发生发展机制、预防、诊断及治疗提供新的思路和治疗靶点。

关键词: 转化生长因子β, 生殖器肿瘤，女（雌）性, 受体，转化生长因子β, CD105

Abstract: Angiogenesis is important in the development and metastasis of tumors, which can meet requirement of organism metabolism and provide vascular access for distant metastasis, and considered to be closely related to prognosis. CD105 also named as Endoglin, which is a member of TGF-β super family receptors, has great specificity in marking tumor neovascularization. Recently, with the further researches in the function and mechanism of tumor cells and stromal cells, CD105 has increasingly application in diagnosis and prognostic evaluation for gynecological malignant tumors. Comprehensive understanding of biological characteristics of CD105 can provide a breakpoint of prevention, diagnosis and therapy for gynecological malignant tumors.

Key words: Transforming growth factor beta, Genital neoplasms，female, Receptors，transforming growth factor beta, CD105