国际妇产科学杂志

国际妇产科学杂志 ›› 2016, Vol. 43 ›› Issue (5): 576-580.

• 综述 • 上一篇    下一篇

piRNA在生殖系统中的研究进展

赵鸿娟，王亚楠，高树军，张媛媛，李光鹏，王煜   

  1. 010050 呼和浩特，内蒙古医科大学附属医院（赵鸿娟，王煜）；内蒙古大学实验动物中心（王亚楠，李光鹏）；内蒙古大学生命科学学院（高树军，张媛媛）
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2016-10-15 发布日期:2016-10-15
  • 通讯作者: 王煜

Research Progress of piRNA in the Reproductive System

ZHAO Hong-juan，WANG Ya-nan，GAO Shu-jun，ZHANG Yuan-yuan，LI Guang-peng，WANG Yu   

  1. Inner Mongolia Medical University Affiliated Hospital，Hohhot 010050，China（ZHAO Hong-juan，WANG Yu）；Research Center for Laboratory Animal Science of Inner Mongolia University，Hohhot 010070，China（WANG Ya-nan，LI Guang-peng）；College of Life Science，Inner Mongolia University，Hohhot 010021，China（GAO Shu-jun，ZHANG Yuan-yuan）
  • Received:1900-01-01 Revised:1900-01-01 Published:2016-10-15 Online:2016-10-15
  • Contact: WANG Yu

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摘要： Piwi蛋白相互作用RNA（piRNA）是一类长度约为30个核苷酸的非编码RNA。目前研究提示piRNA通过与PIWI蛋白家族成员结合后，参与异染色质形成、生殖细胞的发育和维持DNA的完整性。piRNA与小干扰RNA（siRNA）及微小RNA（miRNA）均是近些年发现的非编码小RNA，在功能、分布和分子特征等方面存在着显著不同。piRNA在精子的发生过程中起着重要的生理调节作用，目前对于piRNA的研究逐渐深入，认识也进一步提高。例如，piRNA的结构特点，发挥功能相关作用蛋白，在体内的分布与表达，在生物体内与PIWI发挥作用的方式以及功能。piRNA数据库的建立将对此类小分子RNA的研究有很大的促进作用。

关键词: RNA，未翻译, 生殖细胞, 微RNAs, RNA，小分子干扰, piRNA

Abstract: Piwi-interacting RNA (piRNA) is a group of small RNAs about 30 nucleotides length that isolated from mammalian reproductive cells, which could bind to the Piwi proteins and regulate its corresponding function. piRNA mainly participates in the process of development of germ cells, silence of transposon, formation of heterochromatin, DNA integrity of germ cells, and so on． It contributes to steady heredity of hereditary substance. As small interfering RNA（siRNA）, microRNA（miRNA） and piRNA is a kind of non-coding small RNAs founded in recent years. However, they are different in functions, gene distributions and characteristics. piRNA is essential for physiological modulation of spermiogenesis. The research of piRNA was further investigated, such as structural features, distribution and interactions with PIWI proteins. Furthermore, establishment of piRNA database will facilitate scientific research of piRNA.

Key words: RNA，untranslated, Germ cells, MicroRNAs, RNA，small interfering, PiRNA