国际妇产科学杂志

国际妇产科学杂志 ›› 2017, Vol. 44 ›› Issue (1): 9-12.

• 综述 •    下一篇

microRNA基因甲基化在卵巢癌中的研究

牛蕾蕾   

  1. 北京大学第三医院
  • 收稿日期:2016-09-01 修回日期:2016-11-08 出版日期:2017-02-15 发布日期:2017-03-28
  • 通讯作者: 牛蕾蕾 E-mail:xiaolei911026@126.com
  • 基金资助:
    2016年国家自然科学基金（面上项目）（81572765）

Research of DNA methylation of microRNA in ovarian cancer

Lei-Lei NIU   

  • Received:2016-09-01 Revised:2016-11-08 Published:2017-02-15 Online:2017-03-28
  • Contact: Lei-Lei NIU E-mail:xiaolei911026@126.com

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摘要： DNA甲基化是目前肿瘤中研究最多的表观遗传学机制之一。已有许多研究表明微小RNA（microRNA, miRNA）与卵巢癌的发生、发展、耐药和预后相关。研究卵巢癌中miRNA基因的甲基化可能为卵巢癌提供新的分子诊断和预后标记物，为化疗耐药分析和个性化治疗提供新的临床思路。

关键词: 微小RNA, 甲基化, 卵巢癌

Abstract: DNA methylation is one of the most widespread research in epigenetic about tumor. Recently, it has become clear that miRNA play an important role in ovarian cancer pathogenesis, metastasis, drug resistance, and prognosis. The DNA methylation of miRNA in ovarian cancer may be used as a noninvasive diagnostic and prognostic biomarker in ovarian cancer, and provide a new clinical thought for the analysis of drug resistance and individualized therapy.

Key words: microRNA, methylation, ovarian cancer