关键词: 叉头转录因子类, 多囊卵巢综合征, 胰岛素抗药性, 肿瘤坏死因子α

Abstract: FOXO1, a member of the class O in Forkhead transcription factor (FOX) family, is expressed in many cell types and is involved in many pathological and physiological processes including cell proliferation, apoptosis, autophagy, metabolism, inflammatory response, cytokine expression, immune differentiation, resistance to oxidative stresse and so on. These processes can cause many clinical phenomena such as carcinogenesis, diabetes, cardiovascular disease, host response and the like. Polycystic ovary syndrome (PCOS) as one of the most common endocrine disorders in women of reproductive age, the mechanism remains unclear. FOXO1 may be involved in the pathophysiology of PCOS such as insulin resistance and low-inflammatory reaction. To study the role of FOXO1 in the pathogenesis of PCOS and its complications is helpful to provide new ideas for the treatment strategy of PCOS.

Key words: Forkhead transcription factors, Polycystic ovary syndrome, Insulin resistance, Tumor necrosis factor-alpha