国际妇产科学杂志 ›› 2019, Vol. 46 ›› Issue (4): 474-478.

• 病例报告 • 上一篇    下一篇

宫颈原始神经外胚层肿瘤一例及文献复习

翟莉蓉,郜亚娟,崔满华   

  1. 130041 长春,吉林大学第二医院妇产科
  • 收稿日期:2019-01-22 修回日期:2019-02-22 出版日期:2019-08-15 发布日期:2019-08-15
  • 通讯作者: 崔满华,E-mail:cuimanhua@126.com E-mail:cuimanhua55@126.com

Cervical Primitive Neuroectodermal Tumor: A Case Report and Literature Review

ZHAI Li-rong,GAO Ya-juan,CUI Man-hua   

  1. Department of Obstetrics and Gynecology,The Second Hospital of Jilin University,Changchun 130041,China
  • Received:2019-01-22 Revised:2019-02-22 Published:2019-08-15 Online:2019-08-15
  • Contact: CUI Man-hua,E-mail:cuimanhua@126.com E-mail:cuimanhua55@126.com

摘要: 为探讨宫颈原始神经外胚层肿瘤[primitive neuroectodermal tumor,PNET;又称尤文氏肉瘤(Ewing sarcoma)]的组织起源、临床特征及诊治进展,提高对该种特殊类型宫颈恶性肿瘤的认识,回顾性分析2016年1月吉林大学第二医院收治的1例PNET患者,该患者体检发现宫颈肿物,无特殊临床表现,经手术病理及免疫组织化学(免疫组化)染色确诊,免疫组化显示人白细胞分化抗原99(cluster of differentiation 99,CD99)、波形蛋白(vimentin,VIM)阳性。提示该类肿瘤极为罕见,生长迅速、恶性程度高、侵袭性强、死亡率高、预后极差,目前尚无标准治疗方案,诊断主要依据病理、免疫组化及细胞遗传学。

关键词: 宫颈肿瘤, 原始神经外胚层肿瘤, 尤文氏肉瘤, 临床特点, 诊断, 治疗

Abstract: To investigate the genesis, clinical characteristics, diagnosis and treatment progress of cervical primitive neuroectodermal tumor (PNET), also called Ewing sarcoma, improve the understandings of this special type of cervical malignancies. A case of cervical PNET, at the Second Hospital of Jilin University in January 2016, was analyzed retrospectively. The tumor was found accidently in a routine examination with no clinical manifestations. The patient was finally confirmed by surgical pathologic examination and immunohistochemical staining. Immunohistochemistry was positive for CD99 and vimentin. Cervix PNET is a extremely rare and aggressively invasive tumor with high malignancy and mortality. The diagnosis depends on pathology, immunohistology and cytogenetics and there is no consensus on treatment so far.

Key words: Cervical neoplasm, primitive neuroectodermal tumor, Ewing sarcoma, clinical characteristics, diagnosis, treatment

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