关键词: 宫颈肿瘤, 甘肃, 发病趋势, 发病年龄, 肿瘤分期

Abstract: Objective：To analyze and discuss the spatial distribution, incidence trend and clinical features of the patients with the cervical cancer diagnosed in the First Hospital of Lanzhou university from 2007 to 2017. Methods: Collect the clinical data of 1023 cases of cervical cancer diagnosed in our hospital from 2007 to 2017. Trend analysis and Chi-square test were used to explore its distribution, age changes, clinical features, pathological characteristics and incidence trend. Results:①The cervical cancer patients admitted to our hospital in the past 11 years were mainly in the southeast of Gansu Province, of which Tianshui was the most (173 cases) , followed by Lanzhou (168 cases) , and the northwest of our province was the least, especially Dunhuang (9 cases) . ②The interannual change of the total number of cervical cancer patients treated in our hospital showed increasing trend, the rate of change was 6.98 persons per year, among which Lanzhou had the largest increase at 1.33 per year, and Tianshui had the least change. ③The patients′ age was mainly 40-49 and 50-59 years old, and there was a tendency of aging, that is, the number of 50-59 years old patients increased, while the number of 40-49 years old patients decreased. The proportion of patients in other age groups was small, and there were no significant changes. The average age of the patients ranged from 50 to 59 years old, mainly in the southeast of Gansu Province, including Jiayuguan, Jinchang, Qingyang, etc. The patients aged from 40 to 49 years old were mainly in Gannan Tibetan Autonomous Prefecture and Jiuquan. ④High incidence age of Stage Ⅰa, Ⅰb, Ⅱa and Ⅳ were all 40~49 years old, while Stage Ⅱb and Ⅲ were 50-59 years old. Squamous cell carcinoma was the main pathological type (94.53%) , followed by adenocarcinoma, and adenosquamous carcinoma was less common. ⑤ There were all no statistically significant differences in clinical stage, pathological type or the age of onset of the cervcial cancer patients in 2007-2011 and 2012-2017 (P＞0.05). Conclusions: The confirmed cases of cervical cancer in our hospital are mainly distributed in the southeast of Gansu Province, the annual change is increasing, the age of which is mainly 50~59 years old with an aging trend. The age of onset of stage Ⅰ and Ⅱa cervical cancer was mainly 40-49 years old, and that of Stage Ⅱb and Ⅲ was 50-59 years old, and squamous cell carcinoma was the main pathological type in these age groups.

Key words: Uterine cervical neoplasms, Gansu, Incidence trend, Age of onset, Neoplasm staging