肥胖影响子宫内膜蜕膜化机制的研究进展

doi:10.12280/gjfckx.20210003

摘要/Abstract

摘要：

子宫内膜蜕膜化是胚胎植入、胎盘形成以及维持妊娠的必要条件,蜕膜化受损与多种不良妊娠结局有关。目前肥胖人群显著增多,对健康有不同程度的损害,肥胖女性子宫内膜间质细胞中蜕膜化标志物催乳素和胰岛素样生长因子结合蛋白1的mRNA表达明显降低,且肥胖对蜕膜化过程中涉及的孕激素相关蛋白、胰岛素受体底物2、信号转导与转录激活因子3、Wnt蛋白等相关因子及蜕膜免疫细胞均有影响,认为肥胖与蜕膜化受损具有密切的关系。研究肥胖与子宫内膜蜕膜化受损的相关性,有助于进一步了解子宫内膜蜕膜化受损的发病机制,对预防蜕膜化受损、改善不良妊娠结局具有重要意义。深入开展此方面的研究可能为肥胖型反复妊娠丢失患者的诊治提供新思路。

关键词: 肥胖症, 子宫内膜, 蜕膜化, 基因表达, 免疫,细胞, 蜕膜

Abstract:

Endometrial decidualization is necessary for embryo implantation, placental formation, and maintenance of pregnancy. Impaired decidualization is associated with multiple adverse pregnancy outcomes. At present, the obesity population has increased significantly, which has different degrees of damage to health. The mRNA expression of prolactin and insulin-like growth factor binding protein 1 in the decidual stromal cells of obese women decreased significantly. Obesity affected progesterone-related protein, insulin receptor substrate 2, signal transduction and activator 3, Wnt protein and decidual immune cells involved in decidualization, which was closely related to the impaired decidualization. To study the correlation between obesity and endometrial decidualization damage is helpful to further understand the pathogenesis of endometrial decidualization damage and to prevent decidualization damage and improve the adverse pregnancy outcome. Further research on this aspect may provide a new idea for the diagnosis and treatment of obese patients with recurrent pregnancy loss.

Key words: Obesity, Endometrium, Decidualization, Gene expression, Immunity,cellular, Decidua

王梦瑶, 宫政, 夏天, 窦真, 赵志梅. 肥胖影响子宫内膜蜕膜化机制的研究进展[J]. 国际妇产科学杂志, 2021, 48(6): 642-645.

WANG Meng-yao, GONG Zheng, XIA Tian, DOU Zhen, ZHAO Zhi-mei. Research Progress on the Mechanism of Obesity Influencing Endometrial Decidualization[J]. Journal of International Obstetrics and Gynecology, 2021, 48(6): 642-645.

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