国际妇产科学杂志

国际妇产科学杂志 ›› 2025, Vol. 52 ›› Issue (6): 664-667.doi: 10.12280/gjfckx.20250836

• 产科生理及产科疾病:论著 • 上一篇    下一篇

子痫前期与子代发生先天性心脏病的关联：一项基于2018—2022年中国出生人口队列的前瞻性研究

刘建辉, 阴赪宏, 刘瑞霞, 苏少飞, 祝慧萍, 谢双华, 张恩婕()   

  1. 100026 首都医科大学附属北京妇产医院/北京妇幼保健院中心实验室（刘建辉，阴赪宏，刘瑞霞，苏少飞，谢双华，张恩婕）；首都医科大学公共卫生学院（祝慧萍）
  • 收稿日期:2025-07-30 出版日期:2025-12-15 发布日期:2025-12-30
  • 通讯作者: 张恩婕 E-mail:zhangenjie@mail.ccmu.edu.cn
  • 基金资助:
    首都卫生发展科研专项(2022-2G-2119);国家自然科学基金(82304088);北京市自然科学基金(7252182);国家重点研发计划(2016YFC1000101)

Association between Preeclampsia and the Occurrence of Congenital Heart Disease in Offspring: A Prospective Study Based on the Chinese Birth Cohort from 2018 to 2022

LIU Jian-hui, YIN Cheng-hong, LIU Rui-xia, SU Shao-fei, ZHU Hui-ping, XIE Shuang-hua, ZHANG En-jie()   

  1. Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100026, China (LIU Jian-hui, YIN Cheng-hong, LIU Rui-xia, SU Shao-fei, XIE Shuang-hua, ZHANG En-jie); School of Public Health, Capital Medical University, Beijing 100069, China (ZHU Hui-ping)
  • Received:2025-07-30 Published:2025-12-15 Online:2025-12-30
  • Contact: ZHANG En-jie E-mail:zhangenjie@mail.ccmu.edu.cn

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摘要：

目的：基于2018—2022年中国出生人口队列，分析孕妇子痫前期（preeclampsia，PE）与子代先天性心脏病（congenital heart disease，CHD）发生风险的关系。方法：本研究为前瞻性队列研究，选择2018年2月—2022年12月参加“中国出生人口队列”研究的孕妇为研究对象。采用电子数据采集系统收集基线和随访信息。采用多因素Logistic回归模型分析孕妇PE与子代CHD发生风险的关联。结果：共纳入研究对象152 151名单胎妊娠孕妇，所有孕妇平均年龄为（30.66±4.11）岁，子代CHD发生率为0.88%（1 340例）。本研究中共有4 565例PE孕妇，发生率为3.00%。PE孕妇子代CHD发生率明显高于非PE孕妇（1.31% vs. 0.87%，P=0.002）。多因素Logistic回归模型分析结果显示，孕妇PE与子代发生CHD显著相关（OR=1.434，95%CI：1.101~1.868，P=0.008），PE与子代发生间隔缺损（OR=1.513，95%CI：1.047~2.185，P=0.027）、永存上腔静脉（OR=3.683，95%CI：1.647~8.232，P=0.002）和卵圆孔未闭（OR=3.158，95%CI：1.642~6.075，P=0.001）均呈正向关联。结论：孕妇PE可能增加子代CHD的发生风险。

关键词: 先兆子痫, 心脏缺损，先天性, 队列研究, Logistic模型

Abstract:

Objective: To analyze the relationship between preeclampsia (PE) in pregnant women and the risk of congenital heart disease (CHD) in their offspring, based on the Chinese Birth Cohort from 2018 to 2022. Methods: This was a prospective cohort study. Pregnant women who participated in the "Chinese Birth Cohort" study from February 2018 to December 2022 were selected as the study subjects. An electronic data collection system was used to collect baseline and follow-up information. A multivariate logistic regression model was used to analyze the association between PE in pregnant women and the risk of CHD in their offspring. Results: A total of 152 151 singleton pregnant women were included in this study. The average age of all pregnant women was (30.66±4.11) years. The incidence of CHD in offspring was 0.88% (1 340 cases). There were 4 565 pregnant women with PE in this study, with an incidence of 3.00%. The incidence of CHD in the offspring of pregnant women with PE was significantly higher than that of pregnant women without PE (1.31% vs. 0.87%, P=0.002). The results of the multivariate logistic regression model analysis showed that PE in pregnant women was significantly associated with the occurrence of CHD in offspring (OR=1.434, 95% CI: 1.101-1.868, P=0.008). PE was positively associated with the occurrence of ventricular septal defect (OR=1.513, 95% CI: 1.047-2.185, P=0.027), persistent left superior vena cava (OR=3.683, 95% CI: 1.647-8.232, P=0.002), and patent foramen ovale (OR=3.158, 95% CI: 1.642-6.075, P=0.001) in offspring. Conclusions: PE in pregnant women may increase the risk of CHD in their offspring.

Key words: Pre-eclampsia, Heart defects, congenital, Cohort studies, Logistic models