输卵管高钙血症型小细胞癌一例

doi:10.12280/gjfckx.20251112

摘要/Abstract

摘要：

输卵管小细胞癌（small cell carcinoma of the fallopian tube，SCCFT）是一种罕见的妇科恶性肿瘤，其发病率在所有女性生殖道恶性肿瘤中占比极低，具有高度侵袭性和预后不良的特点，需要病理组织活检和免疫组织化学检查结果才能确诊。报告1例46岁SCCFT病例，患者因腹痛就诊于外院急诊，行腹腔镜下左侧输卵管切除术＋右侧卵巢囊肿剥除术，术后病理考虑输卵管恶性肿瘤，遂就诊于我院，病理会诊后考虑输卵管高钙血症型小细胞癌，遂行腹腔镜全子宫切除术+盆腔淋巴结清扫术+腹主动脉旁淋巴结切除术+左侧卵巢切除术+右侧卵巢和输卵管切除术+直肠前方肿物切除术+阑尾切除术+盆腔粘连松解术+部分大网膜切除补充手术，术后给予紫杉醇+铂类静脉化疗6个周期，术后8个月未见复发及转移。结合此病例总结卵巢/输卵管小细胞癌发病特点、组织病理表现、诊断、治疗及预后，旨在为此类疾病的临床诊治提供参考。

关键词: 输卵管, 卵巢, 癌，小细胞, 诊断, 治疗, 预后

Abstract:

Small cell carcinoma of the fallopian tube (SCCFT) is a rare and highly aggressive gynecological malignancy with an extremely low incidence among all female reproductive tract neoplasms and is characterized by a poor prognosis. Definitive diagnosis requires a combination of histopathological tissue biopsy and immunohistochemical analysis. This report presents a case of 46-year-old female patient diagnosed with SCCFT. The patient initially presented with abdominal pain at an external hospital emergency department and underwent laparoscopic left salpingectomy plus right ovarian cystectomy. Postoperative pathology suggested a malignant tumor of the fallopian tube. Subsequently, the patient was referred to our institution. Following pathological consultation, a diagnosis of hypercalcemic type SCCFT was confirmed. The patient then underwent supplementary surgery consisting of laparoscopic total hysterectomy, pelvic lymphadenectomy, para-aortic lymphadenectomy, left oophorectomy, right salpingo-oophorectomy, resection of a pre-rectal mass, appendectomy, pelvic adhesiolysis and partial omentectomy. Postoperatively, she received six cycles of intravenous chemotherapy with a paclitaxel plus platinum-based regimen. No evidence of recurrence or metastasis was observed at 8 months post-surgery. This case report summarizes the clinical features, histopathological manifestations, diagnosis, treatment, and prognosis of small cell carcinoma of ovary/fallopian tube, aiming to provide a reference for the clinical management of this disease entity.

Key words: Fallopian tube, Ovary, Carcinoma, small cell, Diagnosis, Therapy, Prognosis

王思瑶, 令菲菲, 李红丽, 刘畅. 输卵管高钙血症型小细胞癌一例[J]. 国际妇产科学杂志, 2026, 53(2): 232-236.

WANG Si-yao, LING Fei-fei, LI Hong-li, LIU Chang. A Case Report of Hypercalcemic Type Small Cell Carcinoma of the Fallopian Tube[J]. Journal of International Obstetrics and Gynecology, 2026, 53(2): 232-236.

图/表 1

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